(4-Bromo-2,6-dimethylphenoxy)(tert-butyl)dimethylsilane

Base Information

• Chemical Name: (4-Bromo-2,6-dimethylphenoxy)(tert-butyl)dimethylsilane
• CAS No.: 139229-99-5
• Molecular Formula: C14H23BrOSi
• Molecular Weight: 315.326
• DSSTox Substance ID: DTXSID90566100
• Nikkaji Number: J2.501.522C
• Mol file: 139229-99-5.mol

Synonyms:(4-bromo-2,6-dimethylphenoxy)(tert-butyl)dimethylsilane;139229-99-5;SCHEMBL1716656;DTXSID90566100;GASZMAQKCBQIQS-UHFFFAOYSA-N;EN300-19314177;(4-bromo-2,6-dimethylphenoxy)tert-butyldimethylsilane;(4-bromo-2,6-dimethylphenoxy) tert-butyldimethylsilane;(4-Bromo-2,6-dimethyl-phenoxy)-tert-butyl-dimethyl-silane

Chemical Property of (4-Bromo-2,6-dimethylphenoxy)(tert-butyl)dimethylsilane

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 314.07015
• Heavy Atom Count: 17
• Complexity: 247

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CC(=C1O[Si](C)(C)C(C)(C)C)C)Br

Technology Process of (4-Bromo-2,6-dimethylphenoxy)(tert-butyl)dimethylsilane

There total 1 articles about (4-Bromo-2,6-dimethylphenoxy)(tert-butyl)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.7%

4-bromo-2,6-dimethyl-phenol (2374-05-2) + tert-butyldimethylsilyl chloride (18162-48-6) → 1-Bromo-4<(tert-butyldimethylsilyl)oxy>-3,5-dimethylbenzene (139229-99-5)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield: 83.0%

1-Bromo-4<(tert-butyldimethylsilyl)oxy>-3,5-dimethylbenzene (139229-99-5) + (+/-)-(Z)-3-Methyl-7-phenyl-6-heptenal (149777-47-9) → (+/-)-(Z)-1-<4-<(tert-Butyldimethylsilyl)oxy>-3,5-dimethylphenyl>-3-methyl-7-phenyl-6-hepten-1-ol

Guidance literature:

With tert.-butyl lithium; In diethyl ether; pentane; 1.) -78 deg C, 1 h, 2.) room temp., 7 h;

DOI:10.1021/jo00071a024

Reference yield: 76.0%

methyl 3-(4-(prop-2-yn-1-yloxy)phenyl)propanoate + 1-Bromo-4<(tert-butyldimethylsilyl)oxy>-3,5-dimethylbenzene (139229-99-5) → methyl 3-(4-((3-(4-((tert-butyldimethylsilyl)oxy)-3,5-dimethylphenyl)prop-2-yn-1-yl)oxy)phenyl) propanoate

Guidance literature:

With copper(l) iodide; sodium tetrachloropalladate(II); N,N,N,N,-tetramethylethylenediamine; di‐tert‐butyl‐(1‐phenylindol‐2‐yl)phosphane; In water; at 80 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.cclet.2015.09.002

upstream raw materials:

4-bromo-2,6-dimethyl-phenol

tert-butyldimethylsilyl chloride

Downstream raw materials:

1-<4-<(tert-butyldimethylsilyl)oxy>-3,5-dimethylphenyl>-5-hydroxy-1-pentanone

1-<4-<(tert-butyldimethylsilyl)oxy>-3,5-dimethylphenyl>-6-hydroxy-1-hexanone

1-<4-((tert-butyldimethylsilyl)oxy)-3,5-dimethylphenyl>pent-4-en-1-ol

(+/-)-(E)-1-<4--3,5-dimethylphenyl>-8-(3,5-dimethoxyphenyl)-5-methyl-5-octen-1-ol