101987-89-7 Usage
Description
8-Chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid is a chemical compound with potent antibacterial properties. It is characterized by its unique molecular structure, which includes a cyclopropyl group, two fluorine atoms, and a chlorine atom. 8-Chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid is derived from the quinolinecarboxylic acid family, which is known for its broad-spectrum antimicrobial activity.
Uses
Used in Pharmaceutical Industry:
8-Chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid is used as an antibacterial agent for the treatment of various bacterial infections. Its application is based on its ability to effectively target and inhibit the growth of harmful bacteria, providing a valuable tool in the fight against antibiotic-resistant strains.
Used in Agricultural Industry:
In the agricultural sector, 8-Chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid is used as a veterinary medicine to treat and prevent bacterial infections in livestock. Its application is due to its effectiveness in combating bacterial pathogens that can cause significant health issues and economic losses in the industry.
Used in Research and Development:
8-Chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid is also utilized in the field of research and development, particularly in the study of new antimicrobial agents and understanding the mechanisms of bacterial resistance. Its application in this context is driven by the need to develop innovative solutions to combat the growing threat of antibiotic resistance.
Check Digit Verification of cas no
The CAS Registry Mumber 101987-89-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,9,8 and 7 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 101987-89:
(8*1)+(7*0)+(6*1)+(5*9)+(4*8)+(3*7)+(2*8)+(1*9)=137
137 % 10 = 7
So 101987-89-7 is a valid CAS Registry Number.
101987-89-7Relevant articles and documents
(Fluorocyclopropyl)quinolones. 2. Synthesis and stereochemical structure- activity relationships of chiral 7-(7-amino-5-azaspiro[2.4]heptan-5-yl)-1- (2-fluorocyclopropyl)quinolone antibacterial agents
Kimura,Atarashi,Kawakami,Sato,Hayakawa
, p. 3344 - 3352 (2007/10/02)
A series of novel chiral 7-(7-amino-5-azaspiro[2.4]heptan-5-yl)-8-chloro- 1-(2-fluorocyclopropyl)-quinolones were synthesized as a continuation of a research project of 1-(2-fluorocyclopropyl)-quinolones by considering stereochemical and physicochemical properties of the molecule. Absolute configurations of the 1-(cis-2-fluorocyclopropyl) moiety and the 7-(7-amino- 5-azaspiro-[2.4]heptan-5-yl) moiety were determined by X-ray crystallographic analysis. Stereochemical structure-activity relationship studies indicated that 1-[(1R,2S)-2-fluorocyclopropyl] and 7-[(7S)-amino-5-azaspiro[2.4]heptan- 5-yl] derivatives are more potent against Gram-positive and Gram-negative bacteria than the other stereoisomers and 7-[(7S)-7-amino-5-azaspiro[2.4]- heptan-5-yl]-8-chloro-1-[(1R,2S)-2-fluorocyclopropyl]quinolone (33) is the most potent of all stereoisomers. Pharmacokinetic profiles and physicochemical properties of the selected compounds were also examined, and it was found that 33 (DU-6859a) possesses moderate lipophilicity and good pharmacokinetic profiles.
Process for the synthesis of 3-chloro-2,4,5-trifluorobenzoic acid
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, (2008/06/13)
An improved process for the preparation of 3-chloro-2,4,5-trifluorobenzoic acid is described which involves reaction of a diester of 3,4,5,6-tetrafluoro-1,2-benzenedicarboxylic acid with a substituted amine to afford 3-amino-2,4,5-trifluorobenzoic acid followed by subsequent conversion of the amio intermediate into 3-chloro-2,4,5-trifluorobenzoic acid.
