Technology Process of (S,E)-methyl 3-(4-(2-([1,1′-biphenyl]-4-ylsulfonamido)-3-(1H-indol-3-yl)propoxy)phenyl)acrylate
There total 8 articles about (S,E)-methyl 3-(4-(2-([1,1′-biphenyl]-4-ylsulfonamido)-3-(1H-indol-3-yl)propoxy)phenyl)acrylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-biphenylmonosulfonic acid;
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine;
In
dichloromethane;
for 0.5h;
(S,E)-methyl 3-(4-(2-amino-3-(1H-indol-3-yl)propoxy)phenyl)acrylate hydrochloride;
With
triethylamine;
In
dichloromethane;
for 4h;
DOI:10.1021/jm401877m
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: acetyl chloride / 5 h / 0 - 75 °C
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 4 h / 0 °C
3.1: hydrogenchloride / ethyl acetate / 20 °C
4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 0.5 h
4.2: 4 h
With
hydrogenchloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; acetyl chloride; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; dichloromethane; ethyl acetate;
2.1: |Mitsunobu Displacement;
DOI:10.1021/jm401877m
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 4 h / 0 °C
2.1: hydrogenchloride / ethyl acetate / 20 °C
3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 0.5 h
3.2: 4 h
With
hydrogenchloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; dichloromethane; ethyl acetate;
1.1: |Mitsunobu Displacement;
DOI:10.1021/jm401877m