Technology Process of (2S,3S,6R,8aR)-6-allyl-6-ethyl-3-(hydroxymethyl)-8a-methyl-2-phenyl-5-oxo-2,3,6,7,8,8a-hexahydro-5H-oxazolo<3,2-a>pyridine
There total 2 articles about (2S,3S,6R,8aR)-6-allyl-6-ethyl-3-(hydroxymethyl)-8a-methyl-2-phenyl-5-oxo-2,3,6,7,8,8a-hexahydro-5H-oxazolo<3,2-a>pyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) lithium diisopropylamide / 1.) THF, hexane, -78 deg C, 2.) a) -78 deg C, 55 min, b) 0 deg C, 40 min
2: 1.) lithium diisopropylamide / 1.) THF, hexane, 0 deg C, 3 h, 2.) a) THF, -78 deg C, 2.5 h, b) from -50 deg C to -30 deg C, 45 min
With
lithium diisopropyl amide;
DOI:10.1021/jo00280a040
- Guidance literature:
-
With
lithium diisopropyl amide;
Yield given. Multistep reaction;
1.) THF, hexane, 0 deg C, 3 h, 2.) a) THF, -78 deg C, 2.5 h, b) from -50 deg C to -30 deg C, 45 min;
DOI:10.1021/jo00280a040
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) 1 M Red-Al, 2.) 1 M aq. tetrabutylammonium dihydrogen phosphate / 1.) toluene, RT, 3 d, 2.) ethanol, reflux, 24 h
2: 1.) 9-BBN, 2.) 3 N NaOH, 30percent H2O2 / 1.) THF, 0 deg C, 24 h, 2.) RT, 30 min
3: 840 mg / Jones reagent / acetone / 0.33 h / 25 °C
With
sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; jones reagent; dihydrogen peroxide; tetrabutylammonium dihydrogen phosphate; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
acetone;
DOI:10.1021/jo00280a040