ethyl 2-(4-(dimethylamino)benzylidene)-5-(3'-(ethoxycarbonyl)biphenyl-4-yl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate

Base Information

• Chemical Name: ethyl 2-(4-(dimethylamino)benzylidene)-5-(3'-(ethoxycarbonyl)biphenyl-4-yl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate
• CAS No.: 1394050-87-3
• Molecular Formula: C₃₄H₃₃N₃O₅S
• Molecular Weight: 595.719
• Mol file: 1394050-87-3.mol

Synonyms:

Chemical Property of ethyl 2-(4-(dimethylamino)benzylidene)-5-(3'-(ethoxycarbonyl)biphenyl-4-yl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(4-(dimethylamino)benzylidene)-5-(3'-(ethoxycarbonyl)biphenyl-4-yl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate

There total 3 articles about ethyl 2-(4-(dimethylamino)benzylidene)-5-(3'-(ethoxycarbonyl)biphenyl-4-yl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-(3'-ethoxycarbonyl-biphenyl-4-yl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester (1219015-75-4) + chloroacetic acid (79-11-8) + 4-dimethylamino-benzaldehyde (100-10-7) → ethyl 2-(4-(dimethylamino)benzylidene)-5-(3'-(ethoxycarbonyl)biphenyl-4-yl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate (1394050-87-3)

Guidance literature:

With sodium acetate; acetic anhydride; acetic acid; for 2h; Reflux;

DOI:10.5012/jkcs.2012.56.3.334

Reference yield:

m-bromobenzoic acid (585-76-2) → ethyl 2-(4-(dimethylamino)benzylidene)-5-(3'-(ethoxycarbonyl)biphenyl-4-yl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate (1394050-87-3)

Guidance literature:

Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; caesium carbonate / 1,4-dioxane; water / 8 h / Inert atmosphere; Reflux

2: hydrogenchloride / 12 h / Reflux

3: sodium acetate; acetic anhydride; acetic acid / 2 h / Reflux

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; sodium acetate; acetic anhydride; caesium carbonate; acetic acid; In 1,4-dioxane; water;

DOI:10.5012/jkcs.2012.56.3.334

Reference yield:

4'-formyl-biphenyl-3-carboxylic acid (222180-20-3) → ethyl 2-(4-(dimethylamino)benzylidene)-5-(3'-(ethoxycarbonyl)biphenyl-4-yl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate (1394050-87-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / 12 h / Reflux

2: sodium acetate; acetic anhydride; acetic acid / 2 h / Reflux

With hydrogenchloride; sodium acetate; acetic anhydride; acetic acid;

DOI:10.5012/jkcs.2012.56.3.334

upstream raw materials:

4-(3'-ethoxycarbonyl-biphenyl-4-yl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

chloroacetic acid

4-dimethylamino-benzaldehyde

m-bromobenzoic acid