1219015-75-4

Upstream product

• 141-97-9 ethyl acetoacetate 
• 17356-08-0 thiourea 
• 222180-20-3 4'-formyl-biphenyl-3-carboxylic acid 
• 64-17-5 ethanol 
• 87199-17-5 4-formylphenylboronic acid, 
• 585-76-2 m-bromobenzoic acid 

Downstream Products

• 1367678-11-2 ethyl 4-(3'-(ethoxycarbonyl)biphenyl-4-yl)-2-(4-ethylbenzylthio)-6-methyl-1,4-dihydropyrimidine-5-carboxylate 
• 1367678-05-4 ethyl 2-(benzylthio)-4-(3'-(ethoxycarbonyl)biphenyl-4-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate 
• 1367678-24-7 ethyl 4-(3'-(ethoxycarbonyl)biphenyl-4-yl)-2-(4-isopropylbenzylthio)-6-methyl-1,4-dihydropyrimidine-5-carboxylate 
• 1367678-16-7 ethyl 4-(3'-(ethoxycarbonyl)biphenyl-4-yl)-2-(4-methoxybenzylthio)-6-methyl-1,4-dihydropyrimidine-5-carboxylate 
• 1367678-27-0 ethyl 2-(4-tert-butylbenzylthio)-4-(3'-(ethoxycarbonyl)-biphenyl-4-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate 
• 1367678-14-5 ethyl 4-(3'-(ethoxycarbonyl)biphenyl-4-yl)-2-(4-methylbenzylthio)-6-methyl-1,4-dihydropyrimidine-5-carboxylate 
• 1367678-21-4 ethyl 2-(chlorobenzylthio)-4-(3'-(ethoxycarbonyl)biphenyl-4-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate 
• 1367678-08-7 ethyl 2-(4-bromobenzylthio)-4-(3'-(ethoxycarbonyl)biphenyl-4-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate 
• 1367678-30-5 ethyl 4-(3'-(ethoxycarbonyl)biphenyl-4-yl)-6-methyl-2-(4-nitrobenzylthio)-1,4-dihydropyrimidine-5-carboxylate 
• 1367678-18-9 ethyl 2-(4-(dimethylamino)benzylthio)-4-(3'-(ethoxycarbonyl)biphenyl-4-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate 
• 1394050-90-8 ethyl 2-(4-tert-butylbenzylidene)-5-(3'-(ethoxycarbonyl)biphenyl-4-yl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1394050-84-0 ethyl 2-(4-methylbenzylidene)-5-(3'-(ethoxycarbonyl)biphenyl-4-yl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1394050-88-4 ethyl 2-(4-chlorobenzylidene)-5-(3'-(ethoxycarbonyl)biphenyl-4-yl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1394050-91-9 ethyl 2-(4-nitrobenzylidene)-5-(3'-(ethoxycarbonyl)biphenyl-4-yl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate 

Relevant academic research and scientific papers

Synthesis and biological activity of ethyl 2-(substituted benzylthio)-4-(3-(ethoxycarbonyl)biphenyl-4-yl)-6-methyl-1,4-dihydropyrimidine- 5-carboxylate derivatives

In the present study, a new series of ethyl 2-(substituted benzylthio)-4-(3-(ethoxycarbonyl)-biphenyl-4-yl)-6-methyl-1,4-dihydropyrimidine- 5-carboxylate derivatives was synthesized. The newly synthesized compounds were characterized by 1H-NMR,

Synthesis and biological studies of novel biphenyl-3,5-dihydro-2H- thiazolopyrimidines derivatives

A new series of ethyl 2-(4-substitutedbenzylidene)-5-(3′- (ethoxycarbonyl)biphenyl-4-yl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a] pyrimidine-6-carboxylate derivatives (8a-j) were synthesized. The newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, LCMS mass and C, H, N analyses. All newly synthesized compounds were screened for their In vitro antioxidant activity (Scavenging of hydrogen peroxide, Scavenging of nitric oxide radical, and Lipid peroxidation inhibitory activity), antibacterial (Escheria coli, Pseudonmonas aeruginosa (gram-negative bacteria), Bacillus sub-tillis, Staphylococcus aureus (gram-positive bacteria)) and antifungal (Candida albicans Aspergillus niger) studies.

Synthesis and anti-bacterial activity of new series of 4-(substituted biphenyl-4-yl)-6-methyl-2-oxo/thioxo-1,2,3, 4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

(Chemical Equation Presented) New series of 4-(substituted biphenyl-4-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester and 4-(substituted biphenyl-4-yl)-6-methyl-2-thioxo-1,2,3,4- tetrahydro-pyrimidine-5-carboxylic acid ethyl ester has been synthesized and the structures of the new compounds were established on the basis of 1H NMR, Mass (ES/MS), elemental analysis, and melting point. In-vitro antibacterial activity (MIC activity) was evaluated and compared with standard drugs ciprofloxacin, sparfloxacin, and trovafloxacin. Most of the compounds in this new series have shown moderate antibacterial activity against both Gram-positive and Gram-negative organisms.