C₆₄H₉₄N₃O₁₀⁽¹⁺⁾*Br^(1-)

Base Information

• Chemical Name: C₆₄H₉₄N₃O₁₀⁽¹⁺⁾*Br^(1-)
• CAS No.: 1558052-36-0
• Molecular Formula: Br*C₆₄H₉₄N₃O₁₀
• Molecular Weight: 1145.37
• Mol file: 1558052-36-0.mol

Synonyms:

Chemical Property of C₆₄H₉₄N₃O₁₀⁽¹⁺⁾*Br^(1-)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₄H₉₄N₃O₁₀⁽¹⁺⁾*Br^(1-)

There total 5 articles about C₆₄H₉₄N₃O₁₀⁽¹⁺⁾*Br^(1-) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl cholate (1448-36-8) → C64H94N3O10(1+)*Br(1-) (1558052-36-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 2 h / 0 °C

2.1: sodium azide / N,N-dimethyl-formamide / 6 h / 70 °C

3.1: triphenylphosphine; water / tetrahydrofuran / 12 h / Reflux

3.2: 12 h / 0 °C

4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 24 h / 20 °C

5.1: acetonitrile / 5 h / Reflux

With sodium azide; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.tet.2013.12.068

Reference yield:

methyl 3β-amino-7α,12α-dihydroxy-5β-cholan-24-oate hydrochloride (143435-84-1) → C64H94N3O10(1+)*Br(1-) (1558052-36-0)

Guidance literature:

Multi-step reaction with 2 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 24 h / 20 °C

2: acetonitrile / 5 h / Reflux

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.tet.2013.12.068

Reference yield:

cholic acid (81-25-4) → C64H94N3O10(1+)*Br(1-) (1558052-36-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: hydrogenchloride / 12 h / 20 °C

2.1: triethylamine / dichloromethane / 2 h / 0 °C

3.1: sodium azide / N,N-dimethyl-formamide / 6 h / 70 °C

4.1: triphenylphosphine; water / tetrahydrofuran / 12 h / Reflux

4.2: 12 h / 0 °C

5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 24 h / 20 °C

6.1: acetonitrile / 5 h / Reflux

With hydrogenchloride; sodium azide; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.tet.2013.12.068

upstream raw materials:

methyl cholate

methyl 3β-amino-7α,12α-dihydroxy-5β-cholan-24-oate hydrochloride

cholic acid

Methyl 3α-methanesulphonyloxy-7α,12α-dihydroxy-5β-cholan-24-oate