(S)-2-(2-iodophenethyl)-1,2,3,4-tetrahydroquinoline

Base Information

Chemical Name:(S)-2-(2-iodophenethyl)-1,2,3,4-tetrahydroquinoline
CAS No.:1394351-31-5
Molecular Formula:C₁₇H₁₈IN
Molecular Weight:363.241
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-(2-iodophenethyl)-1,2,3,4-tetrahydroquinoline

Chemical Property:

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Technology Process of (S)-2-(2-iodophenethyl)-1,2,3,4-tetrahydroquinoline

There total 4 articles about (S)-2-(2-iodophenethyl)-1,2,3,4-tetrahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1394351-03-1
1,5-bis(2-iodophenyl)pentan-3-amine

: 1394351-31-5
(S)-2-(2-iodophenethyl)-1,2,3,4-tetrahydroquinoline

: (R)-2-(2-iodophenethyl)-1,2,3,4-tetrahydroquinoline

Guidance literature:: With copper(l) iodide; caesium carbonate; 3,3'-bis-(3,5-bis-trifluoromethyl-phenyl)-[1,1']binaphthalenyl-2,2'-diol; In 1,4-dioxane; at 20 ℃; Overall yield = 83 %; enantioselective reaction;
DOI:10.1021/ja306631z

Reference yield:

: 174585-86-5
2-(2'-bromoethyl)-1-iodobenzene

: 1394351-31-5
(S)-2-(2-iodophenethyl)-1,2,3,4-tetrahydroquinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / Reflux

2.1: water; sodium hydroxide / ethanol

3.1: di-tert-butyl dicarbonate; sodium azide / tetrahydrofuran

3.2: TABA / 60 °C

4.1: copper(l) iodide; 3,3'-bis-(3,5-bis-trifluoromethyl-phenyl)-[1,1']binaphthalenyl-2,2'-diol; caesium carbonate / 1,4-dioxane / 20 °C

With copper(l) iodide; sodium azide; di-tert-butyl dicarbonate; water; potassium carbonate; caesium carbonate; sodium hydroxide; 3,3'-bis-(3,5-bis-trifluoromethyl-phenyl)-[1,1']binaphthalenyl-2,2'-diol; In tetrahydrofuran; 1,4-dioxane; ethanol; 4.1: |Ullmann-Fetvadjian Synthesis;
DOI:10.1021/ja306631z

Reference yield:

: 1394351-80-4
C₂₃H₂₆I₂O₄

: 1394351-31-5
(S)-2-(2-iodophenethyl)-1,2,3,4-tetrahydroquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; sodium hydroxide / ethanol

2.1: di-tert-butyl dicarbonate; sodium azide / tetrahydrofuran

2.2: TABA / 60 °C

3.1: copper(l) iodide; 3,3'-bis-(3,5-bis-trifluoromethyl-phenyl)-[1,1']binaphthalenyl-2,2'-diol; caesium carbonate / 1,4-dioxane / 20 °C

With copper(l) iodide; sodium azide; di-tert-butyl dicarbonate; water; caesium carbonate; sodium hydroxide; 3,3'-bis-(3,5-bis-trifluoromethyl-phenyl)-[1,1']binaphthalenyl-2,2'-diol; In tetrahydrofuran; 1,4-dioxane; ethanol; 3.1: |Ullmann-Fetvadjian Synthesis;
DOI:10.1021/ja306631z