ethyl 6-((tert-butoxycarbonylamino)methyl)picolinate

Base Information

Chemical Name:ethyl 6-((tert-butoxycarbonylamino)methyl)picolinate
CAS No.:1433825-88-7
Molecular Formula:C₁₄H₂₀N₂O₄
Molecular Weight:280.324
Hs Code.:

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Chemical Property of ethyl 6-((tert-butoxycarbonylamino)methyl)picolinate

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Technology Process of ethyl 6-((tert-butoxycarbonylamino)methyl)picolinate

There total 2 articles about ethyl 6-((tert-butoxycarbonylamino)methyl)picolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 97483-79-9
ethyl-6-cyano-2-pyridinecarboxylate

: 1433825-88-7
ethyl 6-((tert-butoxycarbonylamino)methyl)picolinate

Guidance literature:: With hydrogen; In methanol; at 20 ℃; for 24h;
DOI:10.1021/jm400087k

Reference yield:

: 21190-88-5
6-bromopyridine-2-carboxylic acid ethyl ester

: 1433825-88-7
ethyl 6-((tert-butoxycarbonylamino)methyl)picolinate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 16 h / Inert atmosphere; Reflux

2: hydrogen / methanol / 24 h / 20 °C

With pyridine; hydrogen; In methanol;
DOI:10.1021/jm400087k

Reference yield:

: 1433825-88-7
ethyl 6-((tert-butoxycarbonylamino)methyl)picolinate

: 1433826-00-6
1-benzyl 2-ethyl 6-((tert-butoxycarbonylamino)methyl)piperidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; platinum(IV) oxide; acetic acid / 72 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With platinum(IV) oxide; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/jm400087k