C₁₁H₁₁FO₃

Base Information

• Chemical Name: C₁₁H₁₁FO₃
• CAS No.: 1449291-16-0
• Molecular Formula: C₁₁H₁₁FO₃
• Molecular Weight: 210.205
• Mol file: 1449291-16-0.mol

Synonyms:

Chemical Property of C₁₁H₁₁FO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₁H₁₁FO₃

There total 2 articles about C₁₁H₁₁FO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

monomethyl monopotassium malonate (38330-80-2) + 2-fluoro-5-methylbenzoyl chloride (135564-61-3) → C11H11FO3 (1449291-16-0)

Guidance literature:

monomethyl monopotassium malonate; With triethylamine; magnesium chloride; In acetonitrile; at 10 - 50 ℃; Inert atmosphere;

2-fluoro-5-methylbenzoyl chloride; In acetonitrile; at 0 - 70 ℃; Inert atmosphere;

With hydrogenchloride; In water; acetonitrile; pH=5 - 6;

DOI:10.1039/c3cc41690a

Reference yield:

2-fluoro-5-methyl-benzoic acid (321-12-0) → C11H11FO3 (1449291-16-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / 2 h / Reflux

2.1: triethylamine; magnesium chloride / acetonitrile / 10 - 50 °C / Inert atmosphere

2.2: 0 - 70 °C / Inert atmosphere

2.3: pH 5 - 6

With thionyl chloride; triethylamine; magnesium chloride; In acetonitrile;

DOI:10.1039/c3cc41690a

Reference yield: 43.0%

C11H11FO3 (1449291-16-0) + N-methyl benzimidoyl chloride (21737-87-1) → methyl 1,6-dimethyl-4-oxo-2-phenyl-1,4-dihydroquinoline-3-carboxylate (1439356-76-9)

Guidance literature:

C₁₁H₁₁FO₃; N-methyl benzimidoyl chloride; With potassium carbonate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

In N,N-dimethyl-formamide; at 110 ℃; for 1h;

DOI:10.1039/c3cc41690a

upstream raw materials:

2-fluoro-5-methyl-benzoic acid

monomethyl monopotassium malonate

2-fluoro-5-methylbenzoyl chloride

Downstream raw materials:

methyl 1,6-dimethyl-4-oxo-2-phenyl-1,4-dihydroquinoline-3-carboxylate