Technology Process of 3-Pyridinecarboxylic acid,
4-[1-[5-methoxy-1-(phenylsulfonyl)-1H-indol-2-yl]ethyl]-
There total 9 articles about 3-Pyridinecarboxylic acid,
4-[1-[5-methoxy-1-(phenylsulfonyl)-1H-indol-2-yl]ethyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 82 percent / CH2Cl2 / 18 h / Ambient temperature
2: SOCl2 / 1.5 h / Heating
3: CH2Cl2 / 18 h / Ambient temperature
4: 49.5 percent / diethyl ether / 18 h / Ambient temperature
5: 1) BuLi / 1) THF, room temp., 2 h; 2) THF, -13 deg C, then 18 h at room temp.
6: 80 percent / aq. HCl / 18 h
7: 62 percent / activated Zn, aq. HCOOH / 12 h / Heating
With
hydrogenchloride; n-butyllithium; formic acid; thionyl chloride; zinc;
In
diethyl ether; dichloromethane;
DOI:10.1039/P19910003165
- Guidance literature:
-
Multi-step reaction with 6 steps
1: SOCl2 / 18 h / Ambient temperature
2: CH2Cl2 / 18 h / Ambient temperature
3: 1) lithium diisopropylamide / 1) Et2O, -70 deg C, 2 h; 2) Et2O, -50 deg C, then 18 h at room temp.
4: 1) BuLi / 1) THF, room temp., 2 h; 2) THF, -13 deg C, then 18 h at room temp.
5: 80 percent / aq. HCl / 18 h
6: 62 percent / activated Zn, aq. HCOOH / 12 h / Heating
With
hydrogenchloride; n-butyllithium; formic acid; thionyl chloride; zinc; lithium diisopropyl amide;
In
dichloromethane;
DOI:10.1039/P19910003165
