3-Pyridinecarboxylic acid, 4-[1-[5-methoxy-1-(phenylsulfonyl)-1H-indol-2-yl]ethyl]-

Base Information

Chemical Name:3-Pyridinecarboxylic acid, 4-[1-[5-methoxy-1-(phenylsulfonyl)-1H-indol-2-yl]ethyl]-
CAS No.:139260-71-2
Molecular Formula:C23H20N2O5S
Molecular Weight:436.488
Hs Code.:

Synonyms:

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Chemical Property of 3-Pyridinecarboxylic acid, 4-[1-[5-methoxy-1-(phenylsulfonyl)-1H-indol-2-yl]ethyl]-

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Technology Process of 3-Pyridinecarboxylic acid, 4-[1-[5-methoxy-1-(phenylsulfonyl)-1H-indol-2-yl]ethyl]-

There total 9 articles about 3-Pyridinecarboxylic acid, 4-[1-[5-methoxy-1-(phenylsulfonyl)-1H-indol-2-yl]ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 139260-65-4
1-(5-Methoxy-1-phenylsulphonylindol-2-yl)-1-methylfuro<3,4-c>pyridin-3(1H)-one

: 139260-71-2
4-<1-(5-Methoxy-1-phenylsulphonylindol-2-yl)ethyl>nicotinic Acid

Guidance literature:: With formic acid; zinc; for 12h; Heating;
DOI:10.1039/P19910003165

Reference yield:

: 4664-08-8
cinchomeronic anhydride

: 139260-71-2
4-<1-(5-Methoxy-1-phenylsulphonylindol-2-yl)ethyl>nicotinic Acid

Guidance literature:: Multi-step reaction with 7 steps

1: 82 percent / CH₂Cl₂ / 18 h / Ambient temperature

2: SOCl₂ / 1.5 h / Heating

3: CH₂Cl₂ / 18 h / Ambient temperature

4: 49.5 percent / diethyl ether / 18 h / Ambient temperature

5: 1) BuLi / 1) THF, room temp., 2 h; 2) THF, -13 deg C, then 18 h at room temp.

6: 80 percent / aq. HCl / 18 h

7: 62 percent / activated Zn, aq. HCOOH / 12 h / Heating

With hydrogenchloride; n-butyllithium; formic acid; thionyl chloride; zinc; In diethyl ether; dichloromethane;
DOI:10.1039/P19910003165

Reference yield:

: 59-67-6
nicotinic acid

: 139260-71-2
4-<1-(5-Methoxy-1-phenylsulphonylindol-2-yl)ethyl>nicotinic Acid

Guidance literature:: Multi-step reaction with 6 steps

1: SOCl₂ / 18 h / Ambient temperature

2: CH₂Cl₂ / 18 h / Ambient temperature

3: 1) lithium diisopropylamide / 1) Et₂O, -70 deg C, 2 h; 2) Et₂O, -50 deg C, then 18 h at room temp.

4: 1) BuLi / 1) THF, room temp., 2 h; 2) THF, -13 deg C, then 18 h at room temp.

5: 80 percent / aq. HCl / 18 h

6: 62 percent / activated Zn, aq. HCOOH / 12 h / Heating

With hydrogenchloride; n-butyllithium; formic acid; thionyl chloride; zinc; lithium diisopropyl amide; In dichloromethane;
DOI:10.1039/P19910003165