C₂₄H₂₁F₄NO₄S

Base Information

Chemical Name:C₂₄H₂₁F₄NO₄S
CAS No.:1428551-16-9
Molecular Formula:C₂₄H₂₁F₄NO₄S
Molecular Weight:495.495
Hs Code.:

C<sub>24</sub>H<sub>21</sub>F<sub>4</sub>NO<sub>4</sub>S

Synonyms:

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Chemical Property of C₂₄H₂₁F₄NO₄S

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Technology Process of C₂₄H₂₁F₄NO₄S

There total 8 articles about C₂₄H₂₁F₄NO₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79660-46-1,80104-36-5
ethyl 6,7,8-trifluoro-4-hydroxyquinoline-3-carboxylate

: 1428551-16-9
C₂₄H₂₁F₄NO₄S

Guidance literature:: Multi-step reaction with 9 steps

1.1: trichlorophosphate / toluene / 2 h / Reflux; Large scale

2.1: sodium hydrogencarbonate / dichloromethane / 19 h / Reflux; Large scale

3.1: diisobutylaluminium hydride / toluene / 7 h / -5 - 0 °C / Inert atmosphere; Large scale

4.1: phosphorus tribromide / dichloromethane / 2 h / 0 - 20 °C

5.1: toluene / 2 h / Resolution of racemate

6.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 °C / Inert atmosphere

6.2: 3 h / 0 - 20 °C / Inert atmosphere

7.1: hydrogenchloride; water / tetrahydrofuran

8.1: water; sodium hydroxide / tetrahydrofuran

9.1: 1 h / Reflux

With 2,2,6,6-tetramethyl-piperidine; hydrogenchloride; n-butyllithium; water; phosphorus tribromide; diisobutylaluminium hydride; sodium hydrogencarbonate; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; hexane; dichloromethane; toluene; 6.2: |Wittig-Horner Reaction;
DOI:10.1021/op400060z

Reference yield:

: 207231-24-1
ethyl 4-chloro-6,7,8-trifluoroquinoline-3-carboxylate

: 1428551-16-9
C₂₄H₂₁F₄NO₄S

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydrogencarbonate / dichloromethane / 19 h / Reflux; Large scale

2.1: diisobutylaluminium hydride / toluene / 7 h / -5 - 0 °C / Inert atmosphere; Large scale

3.1: phosphorus tribromide / dichloromethane / 2 h / 0 - 20 °C

4.1: toluene / 2 h / Resolution of racemate

5.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 °C / Inert atmosphere

5.2: 3 h / 0 - 20 °C / Inert atmosphere

6.1: hydrogenchloride; water / tetrahydrofuran

7.1: water; sodium hydroxide / tetrahydrofuran

8.1: 1 h / Reflux

With 2,2,6,6-tetramethyl-piperidine; hydrogenchloride; n-butyllithium; water; phosphorus tribromide; diisobutylaluminium hydride; sodium hydrogencarbonate; sodium hydroxide; In tetrahydrofuran; hexane; dichloromethane; toluene; 5.2: |Wittig-Horner Reaction;
DOI:10.1021/op400060z

Reference yield:

: ethyl 4-(4-fluorothiophenyl)-6,7,8-trifluoroquinoline-3-carboxylate

: 1428551-16-9
C₂₄H₂₁F₄NO₄S

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisobutylaluminium hydride / toluene / 7 h / -5 - 0 °C / Inert atmosphere; Large scale

2.1: phosphorus tribromide / dichloromethane / 2 h / 0 - 20 °C

3.1: toluene / 2 h / Resolution of racemate

4.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 °C / Inert atmosphere

4.2: 3 h / 0 - 20 °C / Inert atmosphere

5.1: hydrogenchloride; water / tetrahydrofuran

6.1: water; sodium hydroxide / tetrahydrofuran

7.1: 1 h / Reflux

With 2,2,6,6-tetramethyl-piperidine; hydrogenchloride; n-butyllithium; water; phosphorus tribromide; diisobutylaluminium hydride; sodium hydroxide; In tetrahydrofuran; hexane; dichloromethane; toluene; 4.2: |Wittig-Horner Reaction;
DOI:10.1021/op400060z