(4R)-4-[[3-(2-dimethylaminoethyl)-1H-indol-5-yl]methyl]oxazolidin-2-one

Base Information

Chemical Name:(4R)-4-[[3-(2-dimethylaminoethyl)-1H-indol-5-yl]methyl]oxazolidin-2-one
CAS No.:139264-24-7
Molecular Formula:C16H21N3O2
Molecular Weight:287.35700
Hs Code.:2934990002
UNII:F3YOE57701
Wikidata:Q27277594
Mol file:139264-24-7.mol

Synonyms:Zolmitriptan R-isomer;139264-24-7;Zolmitriptan, (R)-;(4R)-4-[[3-(2-dimethylaminoethyl)-1H-indol-5-yl]methyl]oxazolidin-2-one;UNII-F3YOE57701;Zolmitriptan R-isomer RS [USP];F3YOE57701;(4R)-4-[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]-1,3-oxazolidin-2-one;(R)-4-((3-(2-(Dimethylamino)ethyl)indol-5-yl(methyl)oxazolidin-2-one;2-Oxazolidinone, 4-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)-, (4R)-;2-Oxazolidinone, 4-[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]-, (4R)-;AscoTop;(R)-Zolmitriptan;(R)-4-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]-2-oxazolidinone(Zolmitriptan R-Isomer);(4R)-4-((3-(2-(DIMETHYLAMINO)ETHYL)-1H-INDOL-5-YL)METHYL)-1,3-OXAZOLIDIN-2-ONE;(4R)-4-({3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}methyl)-1,3-oxazolidin-2-one;SCHEMBL40595;AKOS015895148;ZOLMITRIPTAN R-ISOMER [USP-RS];ZOLMITRIPTAN IMPURITY A [EP IMPURITY];ZOLMITRIPTAN R-ISOMER [USP IMPURITY];Q27277594;(R)-4-({3-[2-(Dimethylamino)ethyl]indol-5-yl}methyl)oxazolidin-2-one

Suppliers and Price of (4R)-4-[[3-(2-dimethylaminoethyl)-1H-indol-5-yl]methyl]oxazolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-4-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]-2-oxazolidinone(ZolmitriptanR-Isomer)
5mg
$ 375.00

Crysdot
(R)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)oxazolidin-2-one 95+%
5g
$ 301.00

Crysdot
(R)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)oxazolidin-2-one 95+%
10g
$ 508.00

Biosynth Carbosynth
(4R)-4-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]-2-oxazolidinone
100 mg
$ 2500.00

Biosynth Carbosynth
(4R)-4-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]-2-oxazolidinone
50 mg
$ 1500.00

Biosynth Carbosynth
(4R)-4-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]-2-oxazolidinone
25 mg
$ 1000.00

Biosynth Carbosynth
(4R)-4-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]-2-oxazolidinone
10 mg
$ 700.00

Biosynth Carbosynth
(4R)-4-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]-2-oxazolidinone
5 mg
$ 500.00

AvaChem
Zolmitriptan R-Isomer
10mg
$ 275.00

American Custom Chemicals Corporation
ZOLMITRIPTAN R-ISOMER 95.00%
5MG
$ 455.50

Total 18 raw suppliers

Chemical Property of (4R)-4-[[3-(2-dimethylaminoethyl)-1H-indol-5-yl]methyl]oxazolidin-2-one

Chemical Property:

Melting Point:134-136°C
PSA：60.85000
LogP:1.56290
Storage Temp.:-20°C Freezer
Solubility.:DMSO (Slightly), Water (Slightly)
XLogP3:2.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:287.16337692
Heavy Atom Count:21
Complexity:375

Purity/Quality:

99%, ^*data from raw suppliers

(R)-4-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]-2-oxazolidinone(ZolmitriptanR-Isomer) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)CCC1=CNC2=C1C=C(C=C2)CC3COC(=O)N3
Isomeric SMILES:CN(C)CCC1=CNC2=C1C=C(C=C2)C[C@@H]3COC(=O)N3
Recent EU Clinical Trials:A double-blind, cross-over patient preference study of frovatriptan versus
Uses (R)-4-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]-2-oxazolidinone, is an isomer of Zolmitriptan (Z639000), a Serotonin 5HTID-receptor agonist.

Technology Process of (4R)-4-[[3-(2-dimethylaminoethyl)-1H-indol-5-yl]methyl]oxazolidin-2-one

There total 15 articles about (4R)-4-[[3-(2-dimethylaminoethyl)-1H-indol-5-yl]methyl]oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 139264-17-8,139264-24-7,139264-82-7
zolmitriptan

Guidance literature:: Purification / work up;

Reference yield: 90.0%

: 659738-69-9
(S)-3-(2-dimethylaminoethyl)-5-[2-oxo-1,3-oxazolidin-4-ylmethyl]-1H-indol-2-carboxylic acid

: 139264-17-8,139264-24-7,139264-82-7
zolmitriptan

Guidance literature:: copper(II) oxide; In quinoline; at 200 ℃; for 0.333333h;

Reference yield: 77.0%

ethyl (S)-3-(2-(dimethylamino)ethyl)-5-((2-oxazolidin-4-yl)methyl)-1H-indolecarboxylate hydrochloride: 868622-23-5
ethyl (S)-3-(2-(dimethylamino)ethyl)-5-((2-oxazolidin-4-yl)methyl)-1H-indolecarboxylate hydrochloride

: 139264-17-8,139264-24-7,139264-82-7
zolmitriptan

Guidance literature:: ethyl (S)-3-(2-(dimethylamino)ethyl)-5-((2-oxazolidin-4-yl)methyl)-1H-indolecarboxylate hydrochloride; With water; sodium carbonate; for 2 - 2.5h; Heating / reflux;

With hydrogenchloride; In water; at 15 - 18 ℃; for 3h; Heating / reflux;

With sodium hydroxide; In water; at 15 - 20 ℃; pH=9.75 - 10; Product distribution / selectivity;