4-Amino-1-[(2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-prop-1-ynyl-1H-pyrimidin-2-one

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Chemical Name:4-Amino-1-[(2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-prop-1-ynyl-1H-pyrimidin-2-one
CAS No.:201673-39-4
Molecular Formula:C₃₉H₄₇N₃O₆Si
Molecular Weight:681.904
Hs Code.:

4-Amino-1-[(2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-prop-1-ynyl-1H-pyrimidin-2-one

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Chemical Property of 4-Amino-1-[(2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-prop-1-ynyl-1H-pyrimidin-2-one

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Technology Process of 4-Amino-1-[(2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-prop-1-ynyl-1H-pyrimidin-2-one

There total 7 articles about 4-Amino-1-[(2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-prop-1-ynyl-1H-pyrimidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104267-95-0
3',5'-di-O-(p-toluoyl)-5-iodo-α-2'-desoxyuridine

: 201673-39-4
4-Amino-1-[(2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-prop-1-ynyl-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 6.35 g / CH₃ONa / methanol / 0.75 h / 22 °C

2: 1) CuI, 2) Et₃N / 1) (Ph₃P)4Pd / 1) 1.5 h, 2) 22 h

3: 83 percent / pyridine / 24 h

4: 88 percent / imidazole / pyridine / 48 h / Ambient temperature

5: 1) 1,2,4-triazole, POCl₃, 2) NH₄OH / 1) pyridine, room temperature, overnight, 2) dioxane, H₂O, 1 h

With 1H-imidazole; 1,2,4-Triazole; ammonium hydroxide; copper(l) iodide; sodium methylate; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In pyridine; methanol;
DOI:10.1016/S0040-4020(97)10257-5

Reference yield:

: 4330-21-6
2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride

: 201673-39-4
4-Amino-1-[(2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-prop-1-ynyl-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: p-nitrophenol, pyridine / CH₂Cl₂ / 20 h

2: 6.35 g / CH₃ONa / methanol / 0.75 h / 22 °C

3: 1) CuI, 2) Et₃N / 1) (Ph₃P)4Pd / 1) 1.5 h, 2) 22 h

4: 83 percent / pyridine / 24 h

5: 88 percent / imidazole / pyridine / 48 h / Ambient temperature

6: 1) 1,2,4-triazole, POCl₃, 2) NH₄OH / 1) pyridine, room temperature, overnight, 2) dioxane, H₂O, 1 h

With pyridine; 1H-imidazole; 1,2,4-Triazole; ammonium hydroxide; copper(l) iodide; 4-nitro-phenol; sodium methylate; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In pyridine; methanol; dichloromethane;
DOI:10.1016/S0040-4020(97)10257-5

Reference yield:

: 60110-67-0,162239-35-2
5-iodo-α-2'-desoxyuridine

: 201673-39-4
4-Amino-1-[(2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-prop-1-ynyl-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1) CuI, 2) Et₃N / 1) (Ph₃P)4Pd / 1) 1.5 h, 2) 22 h

2: 83 percent / pyridine / 24 h

3: 88 percent / imidazole / pyridine / 48 h / Ambient temperature

4: 1) 1,2,4-triazole, POCl₃, 2) NH₄OH / 1) pyridine, room temperature, overnight, 2) dioxane, H₂O, 1 h

With 1H-imidazole; 1,2,4-Triazole; ammonium hydroxide; copper(l) iodide; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In pyridine;
DOI:10.1016/S0040-4020(97)10257-5