C₂₁H₂₁NO₅

Base Information

• Chemical Name: C₂₁H₂₁NO₅
• CAS No.: 1427690-81-0
• Molecular Formula: C₂₁H₂₁NO₅
• Molecular Weight: 367.401
• Mol file: 1427690-81-0.mol

Synonyms:

Chemical Property of C₂₁H₂₁NO₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₁NO₅

There total 8 articles about C₂₁H₂₁NO₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

C20H19NO6 (1427690-80-9) + methyl-triphenylphosphonium iodide (2065-66-9) → C21H21NO5 (1427690-81-0) + 1-methyl-5-(1-(3,4,5-trimethoxyphenyl)vinyl)-3-vinyl-1H-indole (1427690-82-1)

Guidance literature:

methyl-triphenylphosphonium iodide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Irradiation;

C₂₀H₁₉NO₆; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jm3015603

Reference yield:

4-methyl-N′-(1-(3,4,5-trimethoxyphenyl)ethylidene)benzenesulfonohydrazide (1170045-84-7) → C21H21NO5 (1427690-81-0)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; lithium tert-butoxide / 1,4-dioxane / 2 h / 110 °C

2: sodium hydroxide / ethanol / Reflux

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; sodium hydroxide; lithium tert-butoxide; In 1,4-dioxane; ethanol;

DOI:10.1021/acs.jmedchem.8b00050

Reference yield:

ethyl 1-methyl-5-(1-(3,4,5-trimetoxyphenyl)vinyl)-1H-indole-3-carboxylate → C21H21NO5 (1427690-81-0)

Guidance literature:

With sodium hydroxide; In ethanol; Reflux;

DOI:10.1021/acs.jmedchem.8b00050

upstream raw materials:

C₂₀H₁₉NO₆

methyl-triphenylphosphonium iodide

5-bromo-1-methyl-H-indole

5-bromo-1H-indole