<3aR,4S,6R,6aS,6(S*),7(R*)>-N<6-<7-<(4-bromobenzyloxy)-(1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-methyl-7-oxo-1(E),3(E),5(E)-heptatrienyl>tetrahydrofuro-<3,4-d>-2,2-dimethyl-1,3-dioxo-4-yl>-6-methoxy-5,7-dimethyl-2(E),4(E)-heptadienyl>acetamide

Base Information

• Chemical Name: <3aR,4S,6R,6aS,6(S*),7(R*)>-N<6-<7-<(4-bromobenzyloxy)-(1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-methyl-7-oxo-1(E),3(E),5(E)-heptatrienyl>tetrahydrofuro-<3,4-d>-2,2-dimethyl-1,3-dioxo-4-yl>-6-methoxy-5,7-dimethyl-2(E),4(E)-heptadienyl>acetamide
• CAS No.: 74189-91-6
• Molecular Formula: C₄₀H₄₉BrN₂O₈
• Molecular Weight: 765.742

Synonyms:

Chemical Property of <3aR,4S,6R,6aS,6(S*),7(R*)>-N<6-<7-<(4-bromobenzyloxy)-(1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-methyl-7-oxo-1(E),3(E),5(E)-heptatrienyl>tetrahydrofuro-<3,4-d>-2,2-dimethyl-1,3-dioxo-4-yl>-6-methoxy-5,7-dimethyl-2(E),4(E)-heptadienyl>acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <3aR,4S,6R,6aS,6(S*),7(R*)>-N<6-<7-<(4-bromobenzyloxy)-(1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-methyl-7-oxo-1(E),3(E),5(E)-heptatrienyl>tetrahydrofuro-<3,4-d>-2,2-dimethyl-1,3-dioxo-4-yl>-6-methoxy-5,7-dimethyl-2(E),4(E)-heptadienyl>acetamide

There total 6 articles about <3aR,4S,6R,6aS,6(S*),7(R*)>-N<6-<7-<(4-bromobenzyloxy)-(1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-methyl-7-oxo-1(E),3(E),5(E)-heptatrienyl>tetrahydrofuro-<3,4-d>-2,2-dimethyl-1,3-dioxo-4-yl>-6-methoxy-5,7-dimethyl-2(E),4(E)-heptadienyl>acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

aurodox → <3aR,4S,6R,6aS,6(S*),7(R*)>-N<6-<7-<(4-bromobenzyloxy)-(1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-methyl-7-oxo-1(E),3(E),5(E)-heptatrienyl>tetrahydrofuro-<3,4-d>-2,2-dimethyl-1,3-dioxo-4-yl>-6-methoxy-5,7-dimethyl-2(E),4(E)-heptadienyl>acetamide (74189-91-6)

Guidance literature:

Multi-step reaction with 4 steps

1: dimethylformamide / 72 h / Ambient temperature

2: 111 mg / acetic acid / 72 h / Ambient temperature

3: 1.65 g / methanol / 1 h

4: 1.47 g / bis(4-nitrophenyl)phosphate / acetone

With Bis(p-nitrophenyl) phosphate; acetic acid; In methanol; N,N-dimethyl-formamide; acetone;

DOI:10.1139/v80-080

Reference yield:

aurodox(4-bromobenzyl) ether → <3aR,4S,6R,6aS,6(S*),7(R*)>-N<6-<7-<(4-bromobenzyloxy)-(1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-methyl-7-oxo-1(E),3(E),5(E)-heptatrienyl>tetrahydrofuro-<3,4-d>-2,2-dimethyl-1,3-dioxo-4-yl>-6-methoxy-5,7-dimethyl-2(E),4(E)-heptadienyl>acetamide (74189-91-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 111 mg / acetic acid / 72 h / Ambient temperature

2: 1.65 g / methanol / 1 h

3: 1.47 g / bis(4-nitrophenyl)phosphate / acetone

With Bis(p-nitrophenyl) phosphate; acetic acid; In methanol; acetone;

DOI:10.1139/v80-080

Reference yield:

2C35H43BrN2O7*2C2H4O2*H2O → <3aR,4S,6R,6aS,6(S*),7(R*)>-N<6-<7-<(4-bromobenzyloxy)-(1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-methyl-7-oxo-1(E),3(E),5(E)-heptatrienyl>tetrahydrofuro-<3,4-d>-2,2-dimethyl-1,3-dioxo-4-yl>-6-methoxy-5,7-dimethyl-2(E),4(E)-heptadienyl>acetamide (74189-91-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.65 g / methanol / 1 h

2: 1.47 g / bis(4-nitrophenyl)phosphate / acetone

With Bis(p-nitrophenyl) phosphate; In methanol; acetone;

DOI:10.1139/v80-080

upstream raw materials:

<2S,3S,4R,5R,7(R*),6(S*)>-N-<7-<5-<7-<(4-bromobenzyloxy)-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl>-6-methyl-7-oxo-1(E),3(E),5(E)-heptatrienyl>tetrahydro-3,4-dihydroxyfuran-2-yl>-6-methoxy-5,7-dimethyl-2(E),4(E)-heptadienyl>acetamide

2,2-dimethoxy-propane

acetone

1-bromomethyl-4-bromobenzene

Downstream raw materials:

<2S,(2β,3β,3aα,5α,6α,6aα)>-hexahydro-5-methoxy-2-(dimethoxymethyl)-6-methylfuro<3,2-b>furan-3-ol 4-bromophenylcarbamic acid ester

<2S-(2β,3β,3aα,5β,6α,6aα)>-hexahydro-5-methoxy-2-(dimethoxymethyl)-6-methylfuro<3,2-b>furan-3-ol 4-bromophenylcarbamic acid ester

4-(4-bromobenzyloxy)-1-methyl-3-pyruvoyl-2(1H)-pyridone

<3aR,4S,6S,6aR,1(R*),2(S*)>-tetrahydro-6-(2-methoxy-1-methyl-3-oxobutyl)furo<3,4-d>1,3-dioxole-4-carboxaldehyde

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