(S)-2-((S)-2-Benzoylamino-3-{(2R,3R,4R,5R,6R)-4,5-diacetoxy-3-acetylamino-6-[(2-tert-butoxycarbonylamino-benzoylamino)-methyl]-tetrahydro-pyran-2-ylcarbamoyl}-propionylamino)-3-(4-hydroxy-3-nitro-phenyl)-propionic acid methyl ester

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Chemical Name:(S)-2-((S)-2-Benzoylamino-3-{(2R,3R,4R,5R,6R)-4,5-diacetoxy-3-acetylamino-6-[(2-tert-butoxycarbonylamino-benzoylamino)-methyl]-tetrahydro-pyran-2-ylcarbamoyl}-propionylamino)-3-(4-hydroxy-3-nitro-phenyl)-propionic acid methyl ester
CAS No.:214473-38-8
Molecular Formula:C₄₅H₅₃N₇O₁₇
Molecular Weight:963.953
Hs Code.:

(S)-2-((S)-2-Benzoylamino-3-{(2R,3R,4R,5R,6R)-4,5-diacetoxy-3-acetylamino-6-[(2-tert-butoxycarbonylamino-benzoylamino)-methyl]-tetrahydro-pyran-2-ylcarbamoyl}-propionylamino)-3-(4-hydroxy-3-nitro-phenyl)-propionic acid methyl ester

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Chemical Property of (S)-2-((S)-2-Benzoylamino-3-{(2R,3R,4R,5R,6R)-4,5-diacetoxy-3-acetylamino-6-[(2-tert-butoxycarbonylamino-benzoylamino)-methyl]-tetrahydro-pyran-2-ylcarbamoyl}-propionylamino)-3-(4-hydroxy-3-nitro-phenyl)-propionic acid methyl ester

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Technology Process of (S)-2-((S)-2-Benzoylamino-3-{(2R,3R,4R,5R,6R)-4,5-diacetoxy-3-acetylamino-6-[(2-tert-butoxycarbonylamino-benzoylamino)-methyl]-tetrahydro-pyran-2-ylcarbamoyl}-propionylamino)-3-(4-hydroxy-3-nitro-phenyl)-propionic acid methyl ester

There total 14 articles about (S)-2-((S)-2-Benzoylamino-3-{(2R,3R,4R,5R,6R)-4,5-diacetoxy-3-acetylamino-6-[(2-tert-butoxycarbonylamino-benzoylamino)-methyl]-tetrahydro-pyran-2-ylcarbamoyl}-propionylamino)-3-(4-hydroxy-3-nitro-phenyl)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 214473-36-6
(S)-3-Benzoylamino-N-[(S)-2-(4-hydroxy-3-nitro-phenyl)-1-methoxycarbonyl-ethyl]-succinamic acid

: 214473-35-5
Acetic acid (2R,3R,4R,5R,6R)-4-acetoxy-5-acetylamino-6-amino-2-[(2-tert-butoxycarbonylamino-benzoylamino)-methyl]-tetrahydro-pyran-3-yl ester

: 214473-38-8
(S)-2-((S)-2-Benzoylamino-3-{(2R,3R,4R,5R,6R)-4,5-diacetoxy-3-acetylamino-6-[(2-tert-butoxycarbonylamino-benzoylamino)-methyl]-tetrahydro-pyran-2-ylcarbamoyl}-propionylamino)-3-(4-hydroxy-3-nitro-phenyl)-propionic acid methyl ester

Guidance literature:: With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In N,N-dimethyl-formamide; for 96h; Ambient temperature;
DOI:10.1016/S0008-6215(98)00011-1

Reference yield:

: 4515-24-6
2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-glucopyranosylamine

: 214473-38-8
(S)-2-((S)-2-Benzoylamino-3-{(2R,3R,4R,5R,6R)-4,5-diacetoxy-3-acetylamino-6-[(2-tert-butoxycarbonylamino-benzoylamino)-methyl]-tetrahydro-pyran-2-ylcarbamoyl}-propionylamino)-3-(4-hydroxy-3-nitro-phenyl)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: pyridine / CH₂Cl₂ / 0 deg C, 1 h, then room temp., 16 h

2: ammonia / methanol / 6 h / 0 °C

3: pyridine / 0 deg C, 1 h, then room temp., 16 h

4: 75 percent / sodium azide / dimethylformamide / 16 h / 80 °C

5: triphenylphosphine / tetrahydrofuran; H₂O / 3 h / Heating

6: tetrahydrofuran; H₂O / 3 h / Ambient temperature

7: pyridine / CH₂Cl₂ / 6 h / Ambient temperature

8: 100 percent / hydrogen / 10percent Pd/C / ethanol / 1 h / Ambient temperature

9: 43 percent / EEDQ / dimethylformamide / 96 h / Ambient temperature

With pyridine; sodium azide; ammonia; hydrogen; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0008-6215(98)00011-1

Reference yield:

: 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-galactopyranosyl azide

: 214473-38-8
(S)-2-((S)-2-Benzoylamino-3-{(2R,3R,4R,5R,6R)-4,5-diacetoxy-3-acetylamino-6-[(2-tert-butoxycarbonylamino-benzoylamino)-methyl]-tetrahydro-pyran-2-ylcarbamoyl}-propionylamino)-3-(4-hydroxy-3-nitro-phenyl)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: hydrogen / platinum oxide / ethanol / 5 h / Ambient temperature

2: pyridine / CH₂Cl₂ / 0 deg C, 1 h, then room temp., 16 h

3: ammonia / methanol / 6 h / 0 °C

4: pyridine / 0 deg C, 1 h, then room temp., 16 h

5: 75 percent / sodium azide / dimethylformamide / 16 h / 80 °C

6: triphenylphosphine / tetrahydrofuran; H₂O / 3 h / Heating

7: tetrahydrofuran; H₂O / 3 h / Ambient temperature

8: pyridine / CH₂Cl₂ / 6 h / Ambient temperature

9: 100 percent / hydrogen / 10percent Pd/C / ethanol / 1 h / Ambient temperature

10: 43 percent / EEDQ / dimethylformamide / 96 h / Ambient temperature

With pyridine; sodium azide; ammonia; hydrogen; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triphenylphosphine; platinum(IV) oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0008-6215(98)00011-1