(S)-3-Benzoylamino-N-[(S)-2-(4-hydroxy-3-nitro-phenyl)-1-methoxycarbonyl-ethyl]-succinamic acid

Base Information

Chemical Name:(S)-3-Benzoylamino-N-[(S)-2-(4-hydroxy-3-nitro-phenyl)-1-methoxycarbonyl-ethyl]-succinamic acid
CAS No.:214473-36-6
Molecular Formula:C₂₁H₂₁N₃O₉
Molecular Weight:459.412
Hs Code.:

Synonyms:(S)-3-Benzoylamino-N-[(S)-2-(4-hydroxy-3-nitro-phenyl)-1-methoxycarbonyl-ethyl]-succinamic acid

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Chemical Property of (S)-3-Benzoylamino-N-[(S)-2-(4-hydroxy-3-nitro-phenyl)-1-methoxycarbonyl-ethyl]-succinamic acid

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Technology Process of (S)-3-Benzoylamino-N-[(S)-2-(4-hydroxy-3-nitro-phenyl)-1-methoxycarbonyl-ethyl]-succinamic acid

There total 4 articles about (S)-3-Benzoylamino-N-[(S)-2-(4-hydroxy-3-nitro-phenyl)-1-methoxycarbonyl-ethyl]-succinamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 214473-42-4
(S)-3-Benzoylamino-N-[(S)-2-(4-hydroxy-3-nitro-phenyl)-1-methoxycarbonyl-ethyl]-succinamic acid tert-butyl ester

: 214473-36-6
(S)-3-Benzoylamino-N-[(S)-2-(4-hydroxy-3-nitro-phenyl)-1-methoxycarbonyl-ethyl]-succinamic acid

Guidance literature:: With trifluoroacetic acid; In neat (no solvent); for 1h; Ambient temperature;
DOI:10.1016/S0008-6215(98)00011-1

Reference yield:

: 54996-28-0
3-nitro-L-tyrosinemethyl ester hydrochloride

: 214473-36-6
(S)-3-Benzoylamino-N-[(S)-2-(4-hydroxy-3-nitro-phenyl)-1-methoxycarbonyl-ethyl]-succinamic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / DhbtOH, DCC, N-ethyldiisopropylamine / dimethylformamide / 0 deg C, 1 h, then room temp., 16 h

2: 100 percent / trifluoroacetic acid / neat (no solvent) / 1 h / Ambient temperature

With N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1016/S0008-6215(98)00011-1

Reference yield:

: 98-88-4
benzoyl chloride

: 214473-36-6
(S)-3-Benzoylamino-N-[(S)-2-(4-hydroxy-3-nitro-phenyl)-1-methoxycarbonyl-ethyl]-succinamic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / aq. Na₂CO₃ / H₂O; dioxane / 0.33 h / Ambient temperature

2: 91 percent / DhbtOH, DCC, N-ethyldiisopropylamine / dimethylformamide / 0 deg C, 1 h, then room temp., 16 h

3: 100 percent / trifluoroacetic acid / neat (no solvent) / 1 h / Ambient temperature

With sodium carbonate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0008-6215(98)00011-1