3-{4-[(2',6'-dimethylbiphenyl-3-yl)methoxy]-2-methylphenyl}propanoic acid

Base Information

Chemical Name:3-{4-[(2',6'-dimethylbiphenyl-3-yl)methoxy]-2-methylphenyl}propanoic acid
CAS No.:691902-31-5
Molecular Formula:C₂₅H₂₆O₃
Molecular Weight:374.48
Hs Code.:

Synonyms:

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Chemical Property of 3-{4-[(2',6'-dimethylbiphenyl-3-yl)methoxy]-2-methylphenyl}propanoic acid

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Technology Process of 3-{4-[(2',6'-dimethylbiphenyl-3-yl)methoxy]-2-methylphenyl}propanoic acid

There total 6 articles about 3-{4-[(2',6'-dimethylbiphenyl-3-yl)methoxy]-2-methylphenyl}propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 691905-26-7
2',6'-dimethyl-[1,1'-biphenyl]-3-carbaldehyde

: 691902-31-5
3-{4-[(2',6'-dimethylbiphenyl-3-yl)methoxy]-2-methylphenyl}propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 6 h / 0 - 20 °C

2: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran

3: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 3 h / 20 °C

With sodium tetrahydroborate; lithium hydroxide monohydrate; tributylphosphine; water; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; 2: Mitsunobu reaction;
DOI:10.1021/jm101405t

Reference yield:

: 1269763-67-8
C₁₁H₁₂O₃

: 691902-31-5
3-{4-[(2',6'-dimethylbiphenyl-3-yl)methoxy]-2-methylphenyl}propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol; water / 16 h / 20 °C

2: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran

3: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 3 h / 20 °C

With lithium hydroxide monohydrate; tributylphosphine; palladium 10% on activated carbon; water; hydrogen; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; water; 2: Mitsunobu reaction;
DOI:10.1021/jm101405t

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 691902-31-5
3-{4-[(2',6'-dimethylbiphenyl-3-yl)methoxy]-2-methylphenyl}propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / 20 h / 80 °C / Inert atmosphere

2: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 6 h / 0 - 20 °C

3: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran

4: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 3 h / 20 °C

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; tributylphosphine; water; sodium carbonate; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; water; toluene; 3: Mitsunobu reaction;
DOI:10.1021/jm101405t