Technology Process of 2,2-dichloro-6,6-difluorocyclohexanol
There total 4 articles about 2,2-dichloro-6,6-difluorocyclohexanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 92 percent / NaOH / H2O / 1.25 h / Ambient temperature
2: 92 percent / BF3*Et2O / 1,2-dichloro-ethane / 3 h / Heating
3: 1.) NaOH, 2.) HF*pyridine / 1.) H2O, room temperature, 1.25 h, 2.) 0 deg C, 10 min; room temperature, 50 min
With
sodium hydroxide; boron trifluoride diethyl etherate; pyridine hydrogenfluoride;
In
water; 1,2-dichloro-ethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 92 percent / BF3*Et2O / 1,2-dichloro-ethane / 3 h / Heating
2: 1.) NaOH, 2.) HF*pyridine / 1.) H2O, room temperature, 1.25 h, 2.) 0 deg C, 10 min; room temperature, 50 min
With
sodium hydroxide; boron trifluoride diethyl etherate; pyridine hydrogenfluoride;
In
1,2-dichloro-ethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 100 percent / NaBH4 / diethyl ether; methanol / 1 h / Ambient temperature
2: 92 percent / NaOH / H2O / 1.25 h / Ambient temperature
3: 92 percent / BF3*Et2O / 1,2-dichloro-ethane / 3 h / Heating
4: 1.) NaOH, 2.) HF*pyridine / 1.) H2O, room temperature, 1.25 h, 2.) 0 deg C, 10 min; room temperature, 50 min
With
sodium hydroxide; sodium tetrahydroborate; boron trifluoride diethyl etherate; pyridine hydrogenfluoride;
In
methanol; diethyl ether; water; 1,2-dichloro-ethane;
