3776-30-5

Basic information

• Product Name: 2,2,6,6-tetrachlorocyclohexan-1-one
• Synonyms: 2,2,6,6-tetrachlorocyclohexan-1-one;Einecs 223-231-0;NSC 238934;Cyclohexanone, 2,2,6,6-tetrachloro-
• CAS NO: 3776-30-5
• Molecular Formula: C₆H₆Cl₄O
• Molecular Weight: 235.92324
• EINECS: 223-231-0
• Mol File: 3776-30-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 83-84℃
• Boiling Point: 329.4°Cat760mmHg
• Flash Point: 138.8°C
• Appearance: /
• Density: 1.53
• Vapor Pressure: 0.000178mmHg at 25°C
• Refractive Index: 1.527
• CAS DataBase Reference: 2,2,6,6-tetrachlorocyclohexan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,6,6-tetrachlorocyclohexan-1-one(3776-30-5)
• EPA Substance Registry System: 2,2,6,6-tetrachlorocyclohexan-1-one(3776-30-5)

Safety Data

• Hazardous Substances Data: 3776-30-5(Hazardous Substances Data)

Usage

General Description

2,2,6,6-tetrachlorocyclohexan-1-one is a chemical compound with a molecular formula C6H8Cl4O. It is a cyclic ketone with four chlorine atoms attached to the cyclohexane ring. 2,2,6,6-tetrachlorocyclohexan-1-one is used as a precursor in the synthesis of other organic compounds and also as an intermediate in the production of pesticides. It is a highly reactive and toxic compound that can pose health hazards if not handled properly. Due to its chlorinated structure, it has limited applications, but it is still used in certain chemical processes and manufacturing industries. Overall, 2,2,6,6-tetrachlorocyclohexan-1-one is a significant chemical compound with various industrial applications.

InChI:InChI=1/C6H6Cl4O/c7-5(8)2-1-3-6(9,10)4(5)11/h1-3H2

Upstream product

• 108-93-0 cyclohexanol 
• 108-94-1 cyclohexanone 
• 7782-50-5 chlorine 
• 22775-31-1 2-oxo-cyclohexane-1,3-dicarboxylic acid 
• 636-82-8 cyclohexene-1-carboxylic acid 

Downstream Products

• 207395-01-5 N-(p-methoxyphenyl)-2,2,6,6-tetrachlorocyclohexaneimine 
• 87-65-0 2,6-Dichlorophenol 
• 6575-24-2 2-(2,6-dichlorophenyl)acetic acid 
• 87-66-1 2-hydroxyresorcinol 
• 123066-65-9 N-phenyl-2,2,6,6-tetrachlorocyclohexaneimine 
• 145706-17-8 2,2-dichloro-6,6-difluorocyclohexanol 
• 71648-20-9 1,3,3-trichloro-7-oxabicyclo<4.1.0>heptane 
• 608-31-1 2,6-Dichloroaniline 
• 30124-19-7 2',6'-(dichlorophenyl)-4-(methoxyphenyl)amine 
• 207395-03-7 N-(chloroacetyl)-2',6'-(dichlorophenyl)-4-(methoxyphenyl)amine 
• 30267-40-4 1-(2',6'-dichlorophenyl)-1,3-dihydro-5-hydroxyindol-2-one 
• 15308-01-7 2-chloro-N-(2',6'-dichlorophenyl)-N-phenylacetamide 

Relevant articles and documents

-

-

Simple and convenient preparation method of 2,6-dichlorophenylacetic acid

The invention provides a simple and convenient preparation method of 2,6-dichlorophenylacetic acid. By using the method, cyclohexanone is used as initial raw materials; chlorination reaction is performed with chlorination reagents to prepare 2,2,6,6-tetrachlorocyclohexanone; then, ethyl malonate condensation and hydrogen chloride removal are performed under the basic conditions, hydrolysis and rearrangement; the 2,6-dichlorophenylacetic acid is prepared through acidification decarboxylation. The used raw materials are cheap and can be easily obtained; the operation is safe, simple and convenient; the waste water quantity is small; the process achieves green and environmental-friendly effects; the product yield and the purity are high; the cost is low.

PRACTICAL SYNTHESIS OF 2,2,5,5-TETRACHLORO-1,6-HEXANEDIOIC ACID, FROM TRANS-1,2-CYCLOHEXANEDIOL OR CYCLOHEXANONE, INVOLVING OXIDATION OF 3,3,6,6-TETRACHLORO-1,2-CYCLOHEXANEDIONE

Trans-1,2-cyclohexanediol was quantitatively converted into 3,3,6,6-tetrachloro-1,2-cyclohexanedione (2) by treatment with chlorine in dimethylformamide.The hydrate of the dione was oxidized by aqueous potassium permanganate to afford the title acid 1 in 91percent overall yield.An alternative low cost preparation was elaborated, providing 2 in 61-74percent yield starting from cyclohexanone in a three step procedure without isolation of intermediates.The reaction seqence involves substitution of α-dichloro- and trichlorocyclohexanones by sodium acetate in acetic acid and chlorination of the resulting 2-hydroxy- and 2-acetoxy-2-cyclohexenones in dimethylformamide.