{(S)-4-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-1,2-dihydro-3-oxa-4a-aza-4-phospha-fluoren-2-yl}-acetonitrile

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Chemical Name:{(S)-4-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-1,2-dihydro-3-oxa-4a-aza-4-phospha-fluoren-2-yl}-acetonitrile
CAS No.:214150-11-5
Molecular Formula:C₄₃H₄₁N₄O₈P
Molecular Weight:772.794
Hs Code.:

{(S)-4-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-1,2-dihydro-3-oxa-4a-aza-4-phospha-fluoren-2-yl}-acetonitrile

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Chemical Property of {(S)-4-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-1,2-dihydro-3-oxa-4a-aza-4-phospha-fluoren-2-yl}-acetonitrile

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Technology Process of {(S)-4-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-1,2-dihydro-3-oxa-4a-aza-4-phospha-fluoren-2-yl}-acetonitrile

There total 3 articles about {(S)-4-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-1,2-dihydro-3-oxa-4a-aza-4-phospha-fluoren-2-yl}-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 191787-36-7
(S)-3-hydroxy-4-(2-indolyl)butyronitrile

: 223932-56-7,214150-11-5
{(S)-4-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-1,2-dihydro-3-oxa-4a-aza-4-phospha-fluoren-2-yl}-acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: PCl₃, Et₃N / tetrahydrofuran / 0 °C

2: tetrahydrofuran / 0 °C

With triethylamine; phosphorus trichloride; In tetrahydrofuran;
DOI:10.1016/S0040-4039(98)01389-6

Reference yield:

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 191787-37-8,214150-09-1
((S)-4-Chloro-1,2-dihydro-3-oxa-4a-aza-4-phospha-fluoren-2-yl)-acetonitrile

: 223932-56-7,214150-11-5
{(S)-4-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-1,2-dihydro-3-oxa-4a-aza-4-phospha-fluoren-2-yl}-acetonitrile

Guidance literature:: In tetrahydrofuran; at 0 ℃;
DOI:10.1016/S0040-4039(98)01389-6

Reference yield:

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 191787-36-7
(S)-3-hydroxy-4-(2-indolyl)butyronitrile

: 223932-56-7,214150-11-5
{(S)-4-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-1,2-dihydro-3-oxa-4a-aza-4-phospha-fluoren-2-yl}-acetonitrile

Guidance literature:: With triethylamine; phosphorus trichloride; Yield given; Multistep reaction; 1.) THF, -78 deg C, 30 min; -78 deg C to 0 deg C, 1 h, 2.) THF, -78 deg C, 30 min;
DOI:10.1021/jo990034t