(R)-3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamine hydrochloride

Base Information

• Chemical Name: (R)-3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamine hydrochloride
• CAS No.: 138614-32-1
• Molecular Formula: C₁₆H₁₆F₃NO*ClH
• Molecular Weight: 331.765
• Mol file: 138614-32-1.mol

Synonyms:138614-32-1;(R)-3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamine hydrochloride;(R)-3-Phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine hydrochloride;(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine;hydrochloride;C16H17ClF3NO;CS-0340946;(R)-3-[4-(Trifluoromethyl)phenoxy]-3-phenylpropan-1-amine hydrochloride;(R)-3-Phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-aminehydrochloride;(3R)-3-PHENYL-3-[4-(TRIFLUOROMETHYL)PHENOXY]PROPAN-1-AMINE HYDROCHLORIDE;Benzenepropanamine,g-[4-(trifluoromethyl)phenoxy]-,hydrochloride(1:1),(gs)-

Chemical Property of (R)-3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamine hydrochloride

Chemical Property:

• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 331.0950763
• Heavy Atom Count: 22
• Complexity: 294

Purity/Quality:

97% ^*data from raw suppliers

1-[(1R)-3-Amino-1-phenylpropoxy]-4-(trifluoromethyl)benzene hydrochloride 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(CCN)OC2=CC=C(C=C2)C(F)(F)F.Cl
• Isomeric SMILES: C1=CC=C(C=C1)[C@@H](CCN)OC2=CC=C(C=C2)C(F)(F)F.Cl

Technology Process of (R)-3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamine hydrochloride

There total 4 articles about (R)-3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-hydroxy-3-phenylpropanenitrile (73627-97-1,121617-17-2,132203-26-0,17190-29-3) → (R)-norfluoxetine hydrochloride (138614-32-1,57226-68-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen, NH₃ / Raney Ni / ethanol / 90 °C / p(NH₃) = 30 psi and p(H₂) = 170 psi

2: 1) NaH / 1) DMSO, 50 deg C, 20 min, 2) DMSO, 90 deg C, 40 min

With ammonia; hydrogen; sodium hydride; nickel; In ethanol;

DOI:10.1016/S0040-4039(00)76212-5

Reference yield:

3-hydroxy-3-phenylpropanenitrile (73627-97-1,121617-17-2,132203-26-0,17190-29-3) → (S)-(+)-norfluoxetine hydrochloride (138614-32-1,57226-68-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen, NH₃ / Raney Ni / ethanol / 90 °C / p(NH₃) = 30 psi and p(H₂) = 170 psi

2: 1) NaH / 1) DMSO, 50 deg C, 20 min, 2) DMSO, 90 deg C, 40 min

With ammonia; hydrogen; sodium hydride; nickel; In ethanol;

DOI:10.1016/S0040-4039(00)76212-5

Reference yield:

4-chlorobenzotrifluoride (98-56-6) + (1R)-3-amino-1-phenyl-1-propanol (138750-31-9) → (R)-norfluoxetine hydrochloride (138614-32-1,57226-68-3)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1) DMSO, 50 deg C, 20 min, 2) DMSO, 90 deg C, 40 min;

DOI:10.1016/S0040-4039(00)76212-5

upstream raw materials:

4-chlorobenzotrifluoride

(1R)-3-amino-1-phenyl-1-propanol

3-hydroxy-3-phenylpropanenitrile

(1S)-3-amino-1-phenyl-1-propanol

Downstream raw materials:

(S)-fluoxetine

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