(S)-2-benzamido-3-((4-methoxyphenethyl)amino)-3-oxopropyl monobenzyl dihydrogen diphosphate

Base Information

• Chemical Name: (S)-2-benzamido-3-((4-methoxyphenethyl)amino)-3-oxopropyl monobenzyl dihydrogen diphosphate
• CAS No.: 1522125-09-2
• Molecular Formula: C₂₆H₂₉N₂O₁₀P₂*Li
• Molecular Weight: 598.412
• Mol file: 1522125-09-2.mol

Synonyms:

Chemical Property of (S)-2-benzamido-3-((4-methoxyphenethyl)amino)-3-oxopropyl monobenzyl dihydrogen diphosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-benzamido-3-((4-methoxyphenethyl)amino)-3-oxopropyl monobenzyl dihydrogen diphosphate

There total 3 articles about (S)-2-benzamido-3-((4-methoxyphenethyl)amino)-3-oxopropyl monobenzyl dihydrogen diphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

(S)-2-benzamido-3-((4-methoxyphenethyl)amino)-3-oxopropyl dihydrogen phosphate (1522124-83-9) + lithium benzyl (1H-imidazol-1-yl)phosphonate (1522124-22-6) → (S)-2-benzamido-3-((4-methoxyphenethyl)amino)-3-oxopropyl monobenzyl dihydrogen diphosphate (1522125-09-2)

Guidance literature:

With zinc(II) chloride; In N,N-dimethyl-formamide; at 45 ℃; for 1.5h;

DOI:10.1021/ja411737c

Reference yield:

monobenzylphosphate (1623-07-0) → (S)-2-benzamido-3-((4-methoxyphenethyl)amino)-3-oxopropyl monobenzyl dihydrogen diphosphate (1522125-09-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; triphenylphosphine / N,N-dimethyl-formamide; acetonitrile / 8.5 h / 20 °C

1.2: 1 h / 0 - 20 °C

2.1: zinc(II) chloride / N,N-dimethyl-formamide / 1.5 h / 45 °C

With triethylamine; triphenylphosphine; zinc(II) chloride; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/ja411737c

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → (S)-2-benzamido-3-((4-methoxyphenethyl)amino)-3-oxopropyl monobenzyl dihydrogen diphosphate (1522125-09-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: phosphoric acid; 1-methyl-1H-imidazole; tri-n-hexylamine / N,N-dimethyl-formamide / 3.5 h / Reflux; Molecular sieve

2.1: triethylamine; triphenylphosphine / N,N-dimethyl-formamide; acetonitrile / 8.5 h / 20 °C

2.2: 1 h / 0 - 20 °C

3.1: zinc(II) chloride / N,N-dimethyl-formamide / 1.5 h / 45 °C

With 1-methyl-1H-imidazole; tri-n-hexylamine; phosphoric acid; triethylamine; triphenylphosphine; zinc(II) chloride; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/ja411737c

upstream raw materials:

(S)-2-benzamido-3-((4-methoxyphenethyl)amino)-3-oxopropyl dihydrogen phosphate

lithium benzyl (1H-imidazol-1-yl)phosphonate

monobenzylphosphate

benzyl alcohol