Thiophosphorofluoridic acid O-{(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester O'-(2-cyano-ethyl) ester

Base Information

• Chemical Name: Thiophosphorofluoridic acid O-{(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester O'-(2-cyano-ethyl) ester
• CAS No.: 171081-21-3
• Molecular Formula: C₄₁H₃₈FN₆O₇PS
• Molecular Weight: 808.827

Synonyms:

Chemical Property of Thiophosphorofluoridic acid O-{(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester O'-(2-cyano-ethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of Thiophosphorofluoridic acid O-{(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester O'-(2-cyano-ethyl) ester

There total 2 articles about Thiophosphorofluoridic acid O-{(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester O'-(2-cyano-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

O-(5'-O-(4,4'-dimethoxytrityl)-N6-benzoyl-2-deoxyadenosin-3'-yl) N,N-diisopropylfluorophosphoramidite (162611-38-3,162611-39-4,171081-09-7) → Thiophosphorofluoridic acid O-{(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester O'-(2-cyano-ethyl) ester (171081-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / tetrazole / acetonitrile / 0.17 h / Ambient temperature

2: S

With 1H-tetrazole; sulfur; In acetonitrile;

DOI:10.1246/cl.1995.727

Reference yield:

Phosphorofluoridous acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester (171081-13-3) → Thiophosphorofluoridic acid O-{(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester O'-(2-cyano-ethyl) ester (171081-21-3)

Guidance literature:

With sulfur;

DOI:10.1246/cl.1995.727

Reference yield:

Thiophosphorofluoridic acid O-{(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester O'-(2-cyano-ethyl) ester (171081-21-3) → O-(5'-O-(4,4'-dimethoxytrityl)-N6-benzoyl-2-deoxyadenosin-3'-yl) thiophosphoromonofluoridate

Guidance literature:

With pyridine; triethylamine; for 0.166667h; Ambient temperature;

DOI:10.1246/cl.1995.727

upstream raw materials:

Phosphorofluoridous acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

O-(5'-O-(4,4'-dimethoxytrityl)-N⁶-benzoyl-2-deoxyadenosin-3'-yl) N,N-diisopropylfluorophosphoramidite

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