171081-13-3

Upstream product

• 109-78-4 3-Hydroxypropionitrile 
• 162611-38-3 O-(5'-O-(4,4'-dimethoxytrityl)-N⁶-benzoyl-2-deoxyadenosin-3'-yl) N,N-diisopropylfluorophosphoramidite 
• 64325-78-6 N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine 
• 191151-90-3 O-(2-cyanoethyl) N,N-diisopropylfluorophosphoramidite 

Downstream Products

• 182370-37-2 O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] hydrogen thiophosphorofluoridate 
• 171081-21-3 Thiophosphorofluoridic acid O-{(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester O'-(2-cyano-ethyl) ester 
• 171081-17-7 Phosphorofluoridic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 
• 171081-18-8 O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(tert-butyl) thiophosphorofluoridate 

Relevant academic research and scientific papers

Trimethylchlorosilane: A novel activating reagent in nucleotide synthesis via the phosphoramidite route

Trimethylchlorosilane (TMSCl) is a remarkably efficient activator in the reaction of phosphorus(III) amides with nucleosides to give phosphorus(III) esters in excellent yield.

Novel unique catalytic activating reagents in synthesis of biophosphates via the phosphoramidite route

Trimethylchlorosilane (TMSCI) and 2,4-dinitrophenol are remarkably efficient activators in reaction of P(III) amides with nucleosides to give P(III) esters in excellent yield.

First Synthesis of Nucleosidyl Phosphorofluoridothioates and a Convenient Synthesis of Nucleosidyl Phosphorofluoridates

The first synthesis of 3'- or 5'-nucleosidyl phosphorofluoridothioates RO-P(S)(OH)F have been accomplished via nucleosidyl phosphoramidofluoridates RO-P(NPr12)F.An analogous convenient procedure has been employed to prepare 3'- or 5'-nucleosidy