(R)-7-chloro-2,2-bis(fluoromethyl)-chroman-4-amine (S)-5-oxopyrrolidine-2-carboxylate

Base Information

Chemical Name:(R)-7-chloro-2,2-bis(fluoromethyl)-chroman-4-amine (S)-5-oxopyrrolidine-2-carboxylate
CAS No.:1537171-73-5
Molecular Formula:C₅H₇NO₃*C₁₁H₁₂ClF₂NO
Molecular Weight:376.788
Hs Code.:

Synonyms:

Suppliers and Price of (R)-7-chloro-2,2-bis(fluoromethyl)-chroman-4-amine (S)-5-oxopyrrolidine-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-7-chloro-2,2-bis(fluoromethyl)-chroman-4-amine (S)-5-oxopyrrolidine-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-7-chloro-2,2-bis(fluoromethyl)-chroman-4-amine (S)-5-oxopyrrolidine-2-carboxylate

There total 6 articles about (R)-7-chloro-2,2-bis(fluoromethyl)-chroman-4-amine (S)-5-oxopyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1537171-71-3
(R)-7-chloro-2,2-bis(fluoromethyl)-chroman-4-aminium chloride

: 98-79-3
L-Pyroglutamic acid

: 1537171-73-5
(R)-7-chloro-2,2-bis(fluoromethyl)-chroman-4-amine (S)-5-oxopyrrolidine-2-carboxylate

Guidance literature:: (R)-7-chloro-2,2-bis(fluoromethyl)-chroman-4-aminium chloride; With sodium hydroxide; In tert-butyl methyl ether; water; at 20 ℃; Large scale;

L-Pyroglutamic acid; In ethanol; tert-butyl methyl ether; for 4h; Large scale;
DOI:10.1021/op400184f

Reference yield:

: 6921-66-0
4-chloro-2-hydroxy acetophenone

: 1537171-73-5
(R)-7-chloro-2,2-bis(fluoromethyl)-chroman-4-amine (S)-5-oxopyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyrrolidine / methanol / 45 °C

2.1: titanium(IV) tetraethanolate / 2-methyltetrahydrofuran / 20 h / 80 °C / Large scale

3.1: sodium tetrahydroborate / tetrahydrofuran; 2-methyltetrahydrofuran / 19 h / -10 °C / Large scale

4.1: acetyl chloride / methanol; tert-butyl methyl ether / 7 h / 20 °C / Large scale

5.1: sodium hydroxide / water; tert-butyl methyl ether / 20 °C / Large scale

5.2: 4 h / Large scale

With pyrrolidine; titanium(IV) tetraethanolate; sodium tetrahydroborate; acetyl chloride; sodium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; methanol; tert-butyl methyl ether; water;
DOI:10.1021/op400184f

Reference yield:

: 1537171-67-7
1-(4-chloro-2-hydroxyphenyl)-4-fluoro-3-(fluoromethyl)-3-hydroxybutan-1-one

: 1537171-73-5
(R)-7-chloro-2,2-bis(fluoromethyl)-chroman-4-amine (S)-5-oxopyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine; trifluoroacetic anhydride / ethanol / 2.2 h / 0 - 5 °C / Large scale

1.2: 8.25 h / 0 - 50 °C / Large scale

2.1: titanium(IV) tetraethanolate / 2-methyltetrahydrofuran / 20 h / 80 °C / Large scale

3.1: sodium tetrahydroborate / tetrahydrofuran; 2-methyltetrahydrofuran / 19 h / -10 °C / Large scale

4.1: acetyl chloride / methanol; tert-butyl methyl ether / 7 h / 20 °C / Large scale

5.1: sodium hydroxide / water; tert-butyl methyl ether / 20 °C / Large scale

5.2: 4 h / Large scale

With pyridine; titanium(IV) tetraethanolate; sodium tetrahydroborate; acetyl chloride; trifluoroacetic anhydride; sodium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; methanol; ethanol; tert-butyl methyl ether; water;
DOI:10.1021/op400184f