Technology Process of 4-Methoxy-3-methoxymethoxy-N-propyl-benzamide
There total 2 articles about 4-Methoxy-3-methoxymethoxy-N-propyl-benzamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) dicyclohexylcarbodiimide, N-hydroxysuccinimide / 1) THF, acetonitrile, rt, 12 h; 2) THF, CH3CM, reflux, 2 h
2: 1.) NaOH, Adogen 464 / 1) CH2Cl2, water, rt, 30 min; 2) CH2Cl2, water, 0 deg C, 1 h
With
sodium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; adogen 464; dicyclohexyl-carbodiimide;
DOI:10.1021/jo981099j
- Guidance literature:
-
With
sodium hydroxide; adogen 464;
Yield given. Multistep reaction;
1) CH2Cl2, water, rt, 30 min; 2) CH2Cl2, water, 0 deg C, 1 h;
DOI:10.1021/jo981099j
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) n-BuLi, 2.) I2 / 1) THF, pentane, -60 deg C, 2 h; 2) THF, pentane, -60 deg C --> rt, 1 h
2: 66 percent / copper bronze / dimethylformamide / 3 h / Heating
3: 1.) n-BuLi, 2.) I2 / 1) THF, pentane, -60 deg C, 2 h; 2) THF, pentane, -60 deg C --> rt, 1 h
4: 82 percent / tetrakis(triphenylphosphine)palladium(0) / dioxane / 14 h / Heating
With
tetrakis(triphenylphosphine) palladium(0); n-butyllithium; iodine; copper;
In
1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jo981099j
