((2S,3R,5R)-2-({[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-5-{5-methyl-4-[1-methyl-pyrrolidin-(2E)-ylideneamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl)-acetic acid

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Chemical Name:((2S,3R,5R)-2-({[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-5-{5-methyl-4-[1-methyl-pyrrolidin-(2E)-ylideneamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl)-acetic acid
CAS No.:222844-65-7
Molecular Formula:C₃₇H₄₁N₅O₅
Molecular Weight:635.763
Hs Code.:

((2S,3R,5R)-2-({[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-5-{5-methyl-4-[1-methyl-pyrrolidin-(2E)-ylideneamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl)-acetic acid

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Chemical Property of ((2S,3R,5R)-2-({[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-5-{5-methyl-4-[1-methyl-pyrrolidin-(2E)-ylideneamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl)-acetic acid

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Technology Process of ((2S,3R,5R)-2-({[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-5-{5-methyl-4-[1-methyl-pyrrolidin-(2E)-ylideneamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl)-acetic acid

There total 9 articles about ((2S,3R,5R)-2-({[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-5-{5-methyl-4-[1-methyl-pyrrolidin-(2E)-ylideneamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 136369-43-2
[(2S,3R,5R)-2-Hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid methyl ester

: 222844-65-7
((2S,3R,5R)-2-({[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-5-{5-methyl-4-[1-methyl-pyrrolidin-(2E)-ylideneamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl)-acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 83 percent / pyridine, DMAP / CHCl₃ / 16 h / 40 °C

2: 78 percent / lithium azide, NaI / dimethylformamide / 16 h / 100 °C

3: POCl₃, NEt₃, 1.2.4-triazole / acetonitrile / 2 h / 0 - 20 °C

4: 99 percent / aq. NH₃ / 1 h / 0 - 20 °C

5: 75 percent / pyridine / methanol / 4 h / Ambient temperature

6: H₂ / Pd/C / methanol / 3 h / 750.06 Torr / Ambient temperature

7: pyridine / 16 h / Ambient temperature

8: LiOH*H₂O / tetrahydrofuran; H₂O / 6 h / Ambient temperature

With pyridine; 1,2,4-Triazole; dmap; lithium hydroxide; ammonium hydroxide; lithium azide; hydrogen; triethylamine; sodium iodide; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4039(99)00389-5

Reference yield:

: 146557-61-1
5'-O-(tert-butyldiphenylsilyl)-3'-C-methylenecarboxylic-3'-deoxythymidine

: 222844-65-7
((2S,3R,5R)-2-({[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-5-{5-methyl-4-[1-methyl-pyrrolidin-(2E)-ylideneamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl)-acetic acid

Guidance literature:: Multi-step reaction with 10 steps

1: 89 percent / DDC, DMAP / CH₂Cl₂ / 16 h / Ambient temperature

2: 78 percent / tetrabutylammonium fluoride / tetrahydrofuran / 3 h / 0 °C

3: 83 percent / pyridine, DMAP / CHCl₃ / 16 h / 40 °C

4: 78 percent / lithium azide, NaI / dimethylformamide / 16 h / 100 °C

5: POCl₃, NEt₃, 1.2.4-triazole / acetonitrile / 2 h / 0 - 20 °C

6: 99 percent / aq. NH₃ / 1 h / 0 - 20 °C

7: 75 percent / pyridine / methanol / 4 h / Ambient temperature

8: H₂ / Pd/C / methanol / 3 h / 750.06 Torr / Ambient temperature

9: pyridine / 16 h / Ambient temperature

10: LiOH*H₂O / tetrahydrofuran; H₂O / 6 h / Ambient temperature

With pyridine; 1,2,4-Triazole; dmap; lithium hydroxide; ammonium hydroxide; lithium azide; tetrabutyl ammonium fluoride; hydrogen; triethylamine; 2`,3`-dideoxycytidine; sodium iodide; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4039(99)00389-5

Reference yield:

: 146557-60-0
[(2S,3R,5R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid methyl ester

: 222844-65-7
((2S,3R,5R)-2-({[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-5-{5-methyl-4-[1-methyl-pyrrolidin-(2E)-ylideneamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl)-acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1: 78 percent / tetrabutylammonium fluoride / tetrahydrofuran / 3 h / 0 °C

2: 83 percent / pyridine, DMAP / CHCl₃ / 16 h / 40 °C

3: 78 percent / lithium azide, NaI / dimethylformamide / 16 h / 100 °C

4: POCl₃, NEt₃, 1.2.4-triazole / acetonitrile / 2 h / 0 - 20 °C

5: 99 percent / aq. NH₃ / 1 h / 0 - 20 °C

6: 75 percent / pyridine / methanol / 4 h / Ambient temperature

7: H₂ / Pd/C / methanol / 3 h / 750.06 Torr / Ambient temperature

8: pyridine / 16 h / Ambient temperature

9: LiOH*H₂O / tetrahydrofuran; H₂O / 6 h / Ambient temperature

With pyridine; 1,2,4-Triazole; dmap; lithium hydroxide; ammonium hydroxide; lithium azide; tetrabutyl ammonium fluoride; hydrogen; triethylamine; sodium iodide; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4039(99)00389-5