C₂₄H₂₈N₂O₄S

Base Information

• Chemical Name: C₂₄H₂₈N₂O₄S
• CAS No.: 1331755-98-6
• Molecular Formula: C₂₄H₂₈N₂O₄S
• Molecular Weight: 440.563
• Mol file: 1331755-98-6.mol

Synonyms:

Chemical Property of C₂₄H₂₈N₂O₄S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₂₈N₂O₄S

There total 7 articles about C₂₄H₂₈N₂O₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(3-Bromo-phenyl)-tetrahydro-pyran-4-carbonitrile (245439-36-5) → C20H18N4S + C24H28N2O4S (1331755-98-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium hydroxide / isopropyl alcohol / Reflux

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium t-butanolate / toluene / 2 h / 75 °C / Inert atmosphere; Reflux; Large scale reaction

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium methylate / 2-methyltetrahydrofuran; methanol / 2 h / 70 °C / Inert atmosphere; Large scale reaction

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium methylate / 2-methyltetrahydrofuran

4.2: silica gel column

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium methylate; potassium hydroxide; sodium t-butanolate; In 2-methyltetrahydrofuran; methanol; isopropyl alcohol; toluene;

DOI:10.1021/op200173g

Reference yield:

(3-bromophenyl)acetonitrile (31938-07-5) → C20H18N4S + C24H28N2O4S (1331755-98-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / tetrahydrofuran; water / Reflux

2.1: potassium hydroxide / isopropyl alcohol / Reflux

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium t-butanolate / toluene / 2 h / 75 °C / Inert atmosphere; Reflux; Large scale reaction

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium methylate / 2-methyltetrahydrofuran; methanol / 2 h / 70 °C / Inert atmosphere; Large scale reaction

5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium methylate / 2-methyltetrahydrofuran

5.2: silica gel column

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium methylate; tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide; sodium hydroxide; sodium t-butanolate; In tetrahydrofuran; 2-methyltetrahydrofuran; methanol; water; isopropyl alcohol; toluene;

DOI:10.1021/op200173g

Reference yield:

para-bromoacetophenone (99-90-1) → C20H18N4S + C24H28N2O4S (1331755-98-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 4 h / 110 °C

2.1: tert-butyl methyl ether / 16 h / 25 °C

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium methylate / 2-methyltetrahydrofuran; methanol / 2 h / 70 °C / Inert atmosphere; Large scale reaction

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium methylate / 2-methyltetrahydrofuran

4.2: silica gel column

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium methylate; In 2-methyltetrahydrofuran; methanol; tert-butyl methyl ether; N,N-dimethyl-formamide;

DOI:10.1021/op200173g

upstream raw materials:

tetrahydro-4-(3-bromophenyl)-2H-pyran-4-carboxamide

4-(3-(triisopropylsilylthio)phenyl)tetrahydro-2H-pyran-4-carboxamide

5-(4-bromophenyl)-1-methyl-1H-pyrazole

4-(3-([4-(1-methyl-1H-pyrazol-5-yl)phenyl]thio)phenyl)tetrahydro-2H-pyran-4-carboxamide

Refernces