(R)-4-Benzyl-4-methyl-dihydro-furan-2-one

Base Information

Chemical Name:(R)-4-Benzyl-4-methyl-dihydro-furan-2-one
CAS No.:80348-92-1
Molecular Formula:C₁₂H₁₄O₂
Molecular Weight:190.242
Hs Code.:

Synonyms:

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Chemical Property of (R)-4-Benzyl-4-methyl-dihydro-furan-2-one

Chemical Property:

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Technology Process of (R)-4-Benzyl-4-methyl-dihydro-furan-2-one

There total 7 articles about (R)-4-Benzyl-4-methyl-dihydro-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: 80348-92-1
(R)-4-Benzyl-4-methyl-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: lithium diisopropylamide / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C

2: lithium diisopropylamide / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C

3: hydrochloric acid / methanol / Ambient temperature

4: lithium aluminum hydride / tetrahydrofuran / Ambient temperature

5: 1.) NaIO₄, 2.) Jones oxidation / 1.) H₂O, AcOEt, rt; 2.) rt

With hydrogenchloride; sodium periodate; lithium aluminium tetrahydride; lithium diisopropyl amide; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1246/cl.1981.1621

Reference yield:

: 101901-31-9
(3R,5S)-3-methyl-5-((trityloxy)methyl)dihydrofuran-2(3H)-one

: 80348-92-1
(R)-4-Benzyl-4-methyl-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: lithium diisopropylamide / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C

2: 47 percent / hydrochloric acid / methanol / Ambient temperature

3: lithium aluminum hydride / tetrahydrofuran / Ambient temperature

4: 1.) NaIO₄, 2.) Jones oxidation / 1.) H₂O, AcOEt, rt; 2.) rt

With hydrogenchloride; sodium periodate; lithium aluminium tetrahydride; lithium diisopropyl amide; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1246/cl.1981.1621

Reference yield:

: 158221-94-4
(2R,4S)-(+)-2-benzyl-4-(trityloxymethyl)-4-butanolide

: 80348-92-1
(R)-4-Benzyl-4-methyl-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: lithium diisopropylamide / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C

2: hydrochloric acid / methanol / Ambient temperature

3: lithium aluminum hydride / tetrahydrofuran / Ambient temperature

4: 1.) NaIO₄, 2.) Jones oxidation / 1.) H₂O, AcOEt, rt; 2.) rt

With hydrogenchloride; sodium periodate; lithium aluminium tetrahydride; lithium diisopropyl amide; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1246/cl.1981.1621