Technology Process of (3S*,4R*)-3-methyl-3-<3,4-(methylenedioxy)benzyl>-4-(3,4-dimethoxybenzyl)-γ-butyrolactone
There total 21 articles about (3S*,4R*)-3-methyl-3-<3,4-(methylenedioxy)benzyl>-4-(3,4-dimethoxybenzyl)-γ-butyrolactone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: lithium diisopropylamide / tetrahydrofuran / 3 h
2: 80.8 g / tetrabutylammonium fluoride / CH2Cl2; tetrahydrofuran / 0.5 h
3: 92 percent / L-Selectride / tetrahydrofuran / 5 h / -20 °C
4: 75 percent / sodium hydride / dimethylformamide / 1 h
5: 4.50 g / diisopropylethylamine / dimethylformamide / 12 h / Ambient temperature
6: 1.) potassium bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 30 min, 2.) THF, 2 h
7: hydrogen, acetic acid, sulfuric acid / Pd/C / 48 h / 2660 Torr / Ambient temperature
8: acetic acid, sulfuric acid / tetrahydrofuran; H2O / 3 h / 40 °C
With
sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; potassium hexamethylsilazane; L-Selectride; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo9601932
- Guidance literature:
-
Multi-step reaction with 8 steps
1: lithium diisopropylamide / tetrahydrofuran / 3 h
2: 80.8 g / tetrabutylammonium fluoride / CH2Cl2; tetrahydrofuran / 0.5 h
3: 92 percent / L-Selectride / tetrahydrofuran / 5 h / -20 °C
4: 75 percent / sodium hydride / dimethylformamide / 1 h
5: 4.50 g / diisopropylethylamine / dimethylformamide / 12 h / Ambient temperature
6: 1.) potassium bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 30 min, 2.) THF, 2 h
7: hydrogen, acetic acid, sulfuric acid / Pd/C / 48 h / 2660 Torr / Ambient temperature
8: acetic acid, sulfuric acid / tetrahydrofuran; H2O / 3 h / 40 °C
With
sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; potassium hexamethylsilazane; L-Selectride; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo9601932
![(2R,3S)-2-Benzo[1,3]dioxol-5-ylmethyl-4-(3,4-dimethoxy-phenyl)-3-methoxymethoxymethyl-2-methyl-butyric acid](/Databaselist/images/loading.webp)
