Technology Process of (2S,3S)-1-Benzoyl-3-ethoxycarbonylmethyl-pyrrolidine-2-carboxylic acid ethyl ester
There total 14 articles about (2S,3S)-1-Benzoyl-3-ethoxycarbonylmethyl-pyrrolidine-2-carboxylic acid ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 84 percent / Na2CO3 / H2O / 1 h / 4 °C
2: 78 percent / (COCl)2 / dimethylsulfoxide; CH2Cl2; triethylamine / 1 h / -50 - 25 °C
3: 72 percent / benzene / 4 h / Ambient temperature
4: NaOEt / 1) benzene, room temp., 0.5 h, 2) ethanol, reflux, 2 h
With
oxalyl dichloride; sodium ethanolate; sodium carbonate;
In
dichloromethane; water; dimethyl sulfoxide; triethylamine; benzene;
DOI:10.1016/S0040-4039(00)86709-X
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 84 percent / Na2CO3 / H2O / 1 h / 4 °C
2: 78 percent / (COCl)2 / dimethylsulfoxide; CH2Cl2; triethylamine / 1 h / -50 - 25 °C
3: 72 percent / benzene / 4 h / Ambient temperature
4: NaOEt / 1) benzene, room temp., 0.5 h, 2) ethanol, reflux, 2 h
With
oxalyl dichloride; sodium ethanolate; sodium carbonate;
In
dichloromethane; water; dimethyl sulfoxide; triethylamine; benzene;
DOI:10.1016/S0040-4039(00)86709-X
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 72 percent / NaH / dimethylformamide / 4 h / 0 - 25 °C
2: 98 percent / 1N HCl / tetrahydrofuran; acetic acid / 1 h / 0 °C
3: 78 percent / (COCl)2 / dimethylsulfoxide; CH2Cl2; triethylamine / 1 h / -50 - 25 °C
4: 72 percent / benzene / 4 h / Ambient temperature
5: NaOEt / 1) benzene, room temp., 0.5 h, 2) ethanol, reflux, 2 h
With
hydrogenchloride; oxalyl dichloride; sodium ethanolate; sodium hydride;
In
tetrahydrofuran; dichloromethane; acetic acid; dimethyl sulfoxide; triethylamine; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4039(00)86709-X
