Technology Process of (R)-2-benzyloxycarbonyl-3-phenylpentane-1,5-dioic acid 1-benzyl 5-ethyl ester
There total 4 articles about (R)-2-benzyloxycarbonyl-3-phenylpentane-1,5-dioic acid 1-benzyl 5-ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; palladium diacetate; oxygen / dimethyl sulfoxide / 28 h / 20 °C
2: potassium permanganate; disodium hydrogenphosphate / tert-butyl alcohol; water / 0.08 h
3: thionyl chloride / 0 - 20 °C
With
(2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; potassium permanganate; disodium hydrogenphosphate; thionyl chloride; oxygen; palladium diacetate;
In
water; dimethyl sulfoxide; tert-butyl alcohol;
DOI:10.1039/c3cc44214d
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium permanganate; disodium hydrogenphosphate / tert-butyl alcohol; water / 0.08 h
2: thionyl chloride / 0 - 20 °C
With
potassium permanganate; disodium hydrogenphosphate; thionyl chloride;
In
water; tert-butyl alcohol;
DOI:10.1039/c3cc44214d
- Guidance literature:
-
Multi-step reaction with 3 steps
1: (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; palladium diacetate; oxygen / dimethyl sulfoxide / 28 h / 20 °C
2: potassium permanganate; disodium hydrogenphosphate / tert-butyl alcohol; water / 0.08 h
3: thionyl chloride / 0 - 20 °C
With
(2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; potassium permanganate; disodium hydrogenphosphate; thionyl chloride; oxygen; palladium diacetate;
In
water; dimethyl sulfoxide; tert-butyl alcohol;
DOI:10.1039/c3cc44214d
