BMS-846370

Base Information

Chemical Name:BMS-846370
CAS No.:1361306-35-5
Molecular Formula:C₂₈H₂₇F₂N₅O₃
Molecular Weight:519.551
Hs Code.:

Synonyms:

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Chemical Property of BMS-846370

Chemical Property:

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Technology Process of BMS-846370

There total 22 articles about BMS-846370 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate

: 1190363-03-1
BMS-846372

: 1361306-35-5
BMS-846370

Guidance literature:: With Chiralpak AD-H analytical column; In methanol; carbon dioxide; at 35 ℃; optical yield given as %ee; Resolution of racemate; Supercritical conditions;
DOI:10.1021/ml300021s

Reference yield:

: 1190363-42-8
(E)-6-(2,3-difluorophenyl)-9-(triisopropylsilyloxy)-8,9-dihydro-7H-cyclohepta[b]pyridine

: 1190363-03-1
BMS-846372

: 1361306-35-5
BMS-846370

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2: palladium on activated charcoal; hydrogen / methanol / 4 h / 760.05 Torr

3: sodium hydride / tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere

4: Chiralpak AD-H analytical column / methanol; carbon dioxide / 35 °C / Resolution of racemate; Supercritical conditions

With palladium on activated charcoal; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; In tetrahydrofuran; methanol; carbon dioxide;
DOI:10.1021/ml300021s

Reference yield:

: 1190363-39-3
9-(triisopropylsilyloxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-6-ol

: 1190363-03-1
BMS-846372

: 1361306-35-5
BMS-846370

Guidance literature:: Multi-step reaction with 7 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / Inert atmosphere; Cooling

1.2: 0.92 h / Inert atmosphere; Cooling

2.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2.2: 18 h / -78 - 20 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene / 1.5 h / 110 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

5.1: palladium on activated charcoal; hydrogen / methanol / 4 h / 760.05 Torr

6.1: sodium hydride / tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere

7.1: Chiralpak AD-H analytical column / methanol; carbon dioxide / 35 °C / Resolution of racemate; Supercritical conditions

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; palladium on activated charcoal; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; sodium carbonate; dimethyl sulfoxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; carbon dioxide; toluene; 1.1: Swern oxidation / 1.2: Swern oxidation / 3.1: Suzuki coupling;
DOI:10.1021/ml300021s