4-nitrophenyl 4-(2,3-dihydro-2-oxoimidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate

Base Information

• Chemical Name: 4-nitrophenyl 4-(2,3-dihydro-2-oxoimidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate
• CAS No.: 1190363-91-7
• Molecular Formula: C₁₈H₁₇N₅O₅
• Molecular Weight: 383.363
• Mol file: 1190363-91-7.mol

Synonyms:4-nitrophenyl 4-(2,3-dihydro-2-oxoimidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate

Chemical Property of 4-nitrophenyl 4-(2,3-dihydro-2-oxoimidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

99.3% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-nitrophenyl 4-(2,3-dihydro-2-oxoimidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate

There total 2 articles about 4-nitrophenyl 4-(2,3-dihydro-2-oxoimidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

2-oxo-1-(piperidinium-4-yl)-2,3-dihydro-1H-imidazo[4,5-b]pyridin-4-ium dichloride (1209456-28-9) → 4-nitrophenyl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)-piperidine-1-carboxylate (1190363-91-7)

Guidance literature:

2-oxo-1-(piperidinium-4-yl)-2,3-dihydro-1H-imidazo[4,5-b]pyridin-4-ium dichloride; With 4-methyl-morpholine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 - 22 ℃; for 0.333333h;

2-oxo-1-(piperidinium-4-yl)-2,3-dihydro-1H-imidazo[4,5-b]pyridin-4-ium dichloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 - 27 ℃; for 2h;

Reference yield:

1-(piperidin-4-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one (185961-99-3) + 4-Nitrophenyl chloroformate (7693-46-1) → 4-nitrophenyl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)-piperidine-1-carboxylate (1190363-91-7)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1016/j.bmcl.2012.02.065

Reference yield: 100.0%

4-nitrophenyl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)-piperidine-1-carboxylate (1190363-91-7) + (6S,9R)-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine-6,9-diol (1289024-24-3) → (6S,9R)-6-(2,3-difluorophenyl)-6-hydroxy-6,7,8,9-tetrahydro-5Hcyclohepta[b]pyridin-9-yl 4-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (1289023-68-2)

Guidance literature:

With sodium hexamethyldisilazane; In N,N-dimethyl-formamide; at 20 ℃; for 3.5h; Inert atmosphere;

upstream raw materials:

2-oxo-1-(piperidinium-4-yl)-2,3-dihydro-1H-imidazo[4,5-b]pyridin-4-ium dichloride

1-(piperidin-4-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one

4-Nitrophenyl chloroformate

Downstream raw materials:

(6R,9R)-6-(2,3-difluorophenyl)-3-(dimethylamino)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate

BMS-846372

(6,9-trans)-6-phenyl-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate

N-((6R,9R)-6-(2,3-difluorophenyl)-3-nitro-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl)-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide