1-(benzyloxycarbonyl)-4,7,10-tris((S)-2-hydroxy-3-(4-(2-(2-hydroxyethoxy)ethoxy)phenoxy)propyl)-1,4,7,10-tetraazacyclododecane

Base Information

• Chemical Name: 1-(benzyloxycarbonyl)-4,7,10-tris((S)-2-hydroxy-3-(4-(2-(2-hydroxyethoxy)ethoxy)phenoxy)propyl)-1,4,7,10-tetraazacyclododecane
• CAS No.: 1334723-08-8
• Molecular Formula: C₅₅H₈₀N₄O₁₇
• Molecular Weight: 1069.26
• Mol file: 1334723-08-8.mol

Synonyms:

Chemical Property of 1-(benzyloxycarbonyl)-4,7,10-tris((S)-2-hydroxy-3-(4-(2-(2-hydroxyethoxy)ethoxy)phenoxy)propyl)-1,4,7,10-tetraazacyclododecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(benzyloxycarbonyl)-4,7,10-tris((S)-2-hydroxy-3-(4-(2-(2-hydroxyethoxy)ethoxy)phenoxy)propyl)-1,4,7,10-tetraazacyclododecane

There total 4 articles about 1-(benzyloxycarbonyl)-4,7,10-tris((S)-2-hydroxy-3-(4-(2-(2-hydroxyethoxy)ethoxy)phenoxy)propyl)-1,4,7,10-tetraazacyclododecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2S)-(+)-3-phenoxy-4-[2-(2-hydroxyethoxy)ethoxy]-1,2-epoxypropane (1334723-06-6) + 1-(benzyloxycarbonyl)-1,4,7,10-tetraazacyclododecane (331230-41-2) → 1-(benzyloxycarbonyl)-4,7,10-tris((S)-2-hydroxy-3-(4-(2-(2-hydroxyethoxy)ethoxy)phenoxy)propyl)-1,4,7,10-tetraazacyclododecane (1334723-08-8)

Guidance literature:

In ethanol;

DOI:10.1007/s10847-010-9782-8

Reference yield:

1-[2-(2-hydroxyethoxy)ethoxy]-4-hydroxybenzene (397244-06-3) → 1-(benzyloxycarbonyl)-4,7,10-tris((S)-2-hydroxy-3-(4-(2-(2-hydroxyethoxy)ethoxy)phenoxy)propyl)-1,4,7,10-tetraazacyclododecane (1334723-08-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2.33 h / 50 °C / Inert atmosphere

1.2: 96 h / 50 °C / Inert atmosphere

2.1: ethanol

With potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1007/s10847-010-9782-8

Reference yield:

1-<2-(2-hydroxyethoxy)ethoxy>-4-benzyloxybenzene (142879-00-3) → 1-(benzyloxycarbonyl)-4,7,10-tris((S)-2-hydroxy-3-(4-(2-(2-hydroxyethoxy)ethoxy)phenoxy)propyl)-1,4,7,10-tetraazacyclododecane (1334723-08-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: palladium on activated charcoal; hydrogen / methanol; dichloromethane / 48 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 2.33 h / 50 °C / Inert atmosphere

2.2: 96 h / 50 °C / Inert atmosphere

3.1: ethanol

With palladium on activated charcoal; hydrogen; potassium carbonate; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1007/s10847-010-9782-8

upstream raw materials:

(2S)-(+)-3-phenoxy-4-[2-(2-hydroxyethoxy)ethoxy]-1,2-epoxypropane

1-(benzyloxycarbonyl)-1,4,7,10-tetraazacyclododecane

1-[2-(2-hydroxyethoxy)ethoxy]-4-hydroxybenzene

4-Benzyloxyphenol

Downstream raw materials:

1,4,7-tris((S)-2-hydroxy-3-(4-(2-(2-hydroxyethoxy)ethoxy)phenoxy)propyl)-1,4,7,10-tetraazacyclododecane