331230-41-2

Upstream product

• 501-53-1 benzyl chloroformate 
• 294-90-6 1,4,7,10-tetraazacyclododecan 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 13795-24-9 benzyl 4-nitrophenyl carbonate 

Downstream Products

• 824401-52-7 1-(benzyloxycarbonyl)-4,7,10-tris(4-tert-butylbenzyl)-1,4,7,10-tetraazacyclododecane*3HCl 
• 331230-42-3 1-benzyloxycarbonyl-4,7,10-tris(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane 
• 748777-77-7 1-methylene-(p-nitrophenol)-1,4,7,10-tetraazacyclododecane-4,7,10-triacetamide 
• 824401-51-6 4,7,10-tris(4-tert-butylbenzyl)-1,4,7,10-tetraazacyclododecane 
• 824401-53-8 1-(tert-butoxycarbonylmethyl)-4,7,10-tris(4-tert-butylbenzyl)-1,4,7,10-tetraazacyclododecane 
• 294-90-6 1,4,7,10-tetraazacyclododecan 
• 1078732-19-0 1-(benzyloxycarbonyl)-4,7,10-tris((2S)-2-hydroxy-3-phenoxypropyl)-1,4,7,10-tetraazacyclododecane 
• 1078732-32-7 1-(benzyloxycarbonyl)-4,7,10-tris((2S)-2-hydroxy-3-[4'-(methyl)phenoxy]propyl)-1,4,7,10-tetraazacyclododecane 
• 1334723-08-8 1-(benzyloxycarbonyl)-4,7,10-tris((S)-2-hydroxy-3-(4-(2-(2-hydroxyethoxy)ethoxy)phenoxy)propyl)-1,4,7,10-tetraazacyclododecane 
• 1334723-09-9 1-(benzyloxycarbonyl)-4,7,10-tris((S)-2-hydroxy-3-(4-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)phenoxy)propyl)-1,4,7,10-tetraazacyclododecane 
• 1268265-45-7 C₄₀H₆₅N₇O₁₁ 
• 1374226-24-0 C₃₄H₅₃N₇O₁₁ 

Relevant academic research and scientific papers

Selective monoprotection of 1,4,7,10-tetraazacyclododecane via direct reaction with 4-nitrophenyl active esters

A simple, one-pot preparation of monoprotected 1,4,7,10-tetraazacyclododecanes via an efficient acylation reaction with 4-nitrophenyl active esters has been developed.

Synthesis of Organosilicon Ligands for Europium (III) and Gadolinium (III) as Potential Imaging Agents

The relaxivity of MRI contrast agents can be increased by increasing the size of the contrast agent and by increasing concentration of the bound gadolinium. Large multi-site ligands able to coordinate several metal centres show increased relaxivity as a result. In this paper, an “aza-type Michael” reaction is used to prepare cyclen derivatives that can be attached to organosilicon frameworks via hydrosilylation reactions. A range of organosilicon frameworks were tested including silsesquioxane cages and dimethylsilylbenzene derivatives. Michael donors with strong electron withdrawing groups could be used to alkylate cyclen on three amine centres in a single step. Hydrosilylation successfully attached these to mono-, di-, and tri-dimethylsilyl-substituted benzene derivatives. The europium and gadolinium complexes were formed and studied using luminescence spectroscopy and relaxometry. This showed the complexes to contain two bound water moles per lanthanide centre and T1 relaxation time measurements demonstrated an increase in relaxivity had been achieved, in particular for the trisubstituted scaffold 1,3,5-tris((pentane-sDO3A)dimethylsilyl)benzene-Gd3. This showed a marked increase in the relaxivity (13.1 r1p/mM?1s?1).

Detection of NAD(P)H-dependent enzyme activity with dynamic luminescence quenching of terbium complexes

We discovered that positively charged terbium complexes bearing 1,4,7,10-tetraazacyclododecane functionalized with amide ligands are highly sensitive to dynamic luminescence quenching by NAD(P)H. We exploited this phenomenon to establish a general time-re