(1E)-N-[1-[[[5-(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[[4-(1,1-dimethylethyl)dimethylsilyl]-oxy]-phenyl]pentyl]-1,3-butadiene-1-sulfonamide

Base Information

• Chemical Name: (1E)-N-[1-[[[5-(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[[4-(1,1-dimethylethyl)dimethylsilyl]-oxy]-phenyl]pentyl]-1,3-butadiene-1-sulfonamide
• CAS No.: 1421663-84-4
• Molecular Formula: C₂₁H₃₅NO₄SSi
• Molecular Weight: 425.665
• Mol file: 1421663-84-4.mol

Synonyms:

Chemical Property of (1E)-N-[1-[[[5-(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[[4-(1,1-dimethylethyl)dimethylsilyl]-oxy]-phenyl]pentyl]-1,3-butadiene-1-sulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1E)-N-[1-[[[5-(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[[4-(1,1-dimethylethyl)dimethylsilyl]-oxy]-phenyl]pentyl]-1,3-butadiene-1-sulfonamide

There total 11 articles about (1E)-N-[1-[[[5-(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[[4-(1,1-dimethylethyl)dimethylsilyl]-oxy]-phenyl]pentyl]-1,3-butadiene-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C27H49NO4SSi2 → (1E)-N-[1-[[[5-(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[[4-(1,1-dimethylethyl)dimethylsilyl]-oxy]-phenyl]pentyl]-1,3-butadiene-1-sulfonamide (1421663-84-4)

Guidance literature:

C₂₇H₄₉NO₄SSi₂; With lithium acetate; In water; N,N-dimethyl-formamide; at 75 ℃; for 6h; Inert atmosphere;

With ammonium chloride; In water; ethyl acetate; N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1139/cjc-2012-0340

Reference yield:

C12H15NO4S → (1E)-N-[1-[[[5-(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[[4-(1,1-dimethylethyl)dimethylsilyl]-oxy]-phenyl]pentyl]-1,3-butadiene-1-sulfonamide (1421663-84-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: 1H-imidazole; dmap / acetonitrile / 2 h / 20 °C / Inert atmosphere

3.1: dmap; triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

4.1: potassium tert-butylate / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: 13 h / -78 - 20 °C / Inert atmosphere

5.1: lithium acetate / water; N,N-dimethyl-formamide / 6 h / 75 °C / Inert atmosphere

5.2: 20 °C

With 1H-imidazole; dmap; lithium borohydride; potassium tert-butylate; lithium acetate; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1139/cjc-2012-0340

Reference yield:

C12H19NO4S → (1E)-N-[1-[[[5-(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[[4-(1,1-dimethylethyl)dimethylsilyl]-oxy]-phenyl]pentyl]-1,3-butadiene-1-sulfonamide (1421663-84-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 1H-imidazole; dmap / acetonitrile / 2 h / 20 °C / Inert atmosphere

2.1: dmap; triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: 13 h / -78 - 20 °C / Inert atmosphere

4.1: lithium acetate / water; N,N-dimethyl-formamide / 6 h / 75 °C / Inert atmosphere

4.2: 20 °C

With 1H-imidazole; dmap; potassium tert-butylate; lithium acetate; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1139/cjc-2012-0340

upstream raw materials:

C₂₄H₄₇NO₄SSi₂

C₂₉H₅₅NO₆SSi₂

4-methoxy-benzaldehyde

ethyl 2-cyano-3-(4-methoxyphenyl)prop-2-enoate