4-[(2R,4R)-1-(3,5-Dichloro-phenyl)-2-isopropyl-4-methyl-5-oxo-3-(2,2,2-trifluoro-acetyl)-imidazolidin-4-ylmethyl]-benzonitrile

Base Information

• Chemical Name: 4-[(2R,4R)-1-(3,5-Dichloro-phenyl)-2-isopropyl-4-methyl-5-oxo-3-(2,2,2-trifluoro-acetyl)-imidazolidin-4-ylmethyl]-benzonitrile
• CAS No.: 835917-09-4
• Molecular Formula: C₂₃H₂₀Cl₂F₃N₃O₂
• Molecular Weight: 498.332
• Mol file: 835917-09-4.mol

Synonyms:

Chemical Property of 4-[(2R,4R)-1-(3,5-Dichloro-phenyl)-2-isopropyl-4-methyl-5-oxo-3-(2,2,2-trifluoro-acetyl)-imidazolidin-4-ylmethyl]-benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(2R,4R)-1-(3,5-Dichloro-phenyl)-2-isopropyl-4-methyl-5-oxo-3-(2,2,2-trifluoro-acetyl)-imidazolidin-4-ylmethyl]-benzonitrile

There total 1 articles about 4-[(2R,4R)-1-(3,5-Dichloro-phenyl)-2-isopropyl-4-methyl-5-oxo-3-(2,2,2-trifluoro-acetyl)-imidazolidin-4-ylmethyl]-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-cyanobenzyl bromide (17201-43-3) + (2R,5R)-3-(3,5-dichlorophenyl)-2-isopropyl-5-methyl-1-(2,2,2-trichloroacetyl)-imidazolidin-4-one (341027-25-6) → 4-[(2R,4R)-1-(3,5-Dichloro-phenyl)-2-isopropyl-4-methyl-5-oxo-3-(2,2,2-trifluoro-acetyl)-imidazolidin-4-ylmethyl]-benzonitrile (835917-09-4)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -15 ℃;

DOI:10.1016/j.tetlet.2004.11.065

Reference yield:

4-[(2R,4R)-1-(3,5-Dichloro-phenyl)-2-isopropyl-4-methyl-5-oxo-3-(2,2,2-trifluoro-acetyl)-imidazolidin-4-ylmethyl]-benzonitrile (835917-09-4) → 2-amino-3-(4-cyano-phenyl)-N-(3,5-dichloro-phenyl)-2-methyl-propionamide (321724-11-2)

Guidance literature:

4-[(2R,4R)-1-(3,5-Dichloro-phenyl)-2-isopropyl-4-methyl-5-oxo-3-(2,2,2-trifluoro-acetyl)-imidazolidin-4-ylmethyl]-benzonitrile; With sodium hydroxide; N-benzyl-trimethylammonium hydroxide; In 1,4-dioxane; at 45 ℃;

With hydrogenchloride; at 50 ℃;

DOI:10.1016/j.tetlet.2004.11.065

Reference yield:

4-[(2R,4R)-1-(3,5-Dichloro-phenyl)-2-isopropyl-4-methyl-5-oxo-3-(2,2,2-trifluoro-acetyl)-imidazolidin-4-ylmethyl]-benzonitrile (835917-09-4) → 2-(2-amino-acetylamino)-3-(4-cyano-phenyl)-N-(3,5-dichloro-phenyl)-2-methyl-propionamide (835917-13-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: BnMe₃NOH; NaOH / dioxane / 45 °C

1.2: aq. HCl / 50 °C

2.1: tBuCOCl / tetrahydrofuran / 0 - 10 °C

3.1: TsOH*H₂O / methanol / 50 °C

With sodium hydroxide; pivaloyl chloride; N-benzyl-trimethylammonium hydroxide; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; methanol;

DOI:10.1016/j.tetlet.2004.11.065

upstream raw materials:

4-cyanobenzyl bromide

(2R,5R)-3-(3,5-dichlorophenyl)-2-isopropyl-5-methyl-1-(2,2,2-trichloroacetyl)-imidazolidin-4-one

Downstream raw materials:

2-amino-3-(4-cyano-phenyl)-N-(3,5-dichloro-phenyl)-2-methyl-propionamide

4-[1-(3,5-dichloro-phenyl)-3-methyl-2,5-dioxo-2,3,5,6-tetrahydro-1H-imidazo[1,2-a]imidazol-3-ylmethyl]-benzonitrile

2-(2-amino-acetylamino)-3-(4-cyano-phenyl)-N-(3,5-dichloro-phenyl)-2-methyl-propionamide

(R)-3-(4-cyanobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-imidazo[1,2-a]-imidazol-2-one