Technology Process of 7ξ,8ξ-epoxy-3-hydroxy-1,3,5(10)-estratrien-17-one
There total 2 articles about 7ξ,8ξ-epoxy-3-hydroxy-1,3,5(10)-estratrien-17-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
for 1.5h;
DOI:10.1016/0039-128X(87)90015-8
- Guidance literature:
-
Equilin, Monoperphthalsaeure-aethylacetat;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 30 percent / I2, NH4OH / methanol / 1 h / Ambient temperature
2: 58 percent / CH(OEt)3, p-toluenesulfonic acid / CH2Cl2 / 2 h
3: 87 percent / CuCl2, 15-crown-5-ether / dimethylformamide / 100 °C
4: 94 percent / tetrahydrofuran; acetic acid; H2O / 0.25 h / Heating
With
ammonium hydroxide; 15-crown-5; iodine; toluene-4-sulfonic acid; orthoformic acid triethyl ester; copper dichloride;
In
tetrahydrofuran; methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/0039-128X(87)90015-8
