Technology Process of 4c-Methyl-cyclohexan-1r-carbonsaeure-chlorid
There total 1 articles about 4c-Methyl-cyclohexan-1r-carbonsaeure-chlorid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
oxalyl dichloride;
In
dichloromethane;
at 0 - 20 ℃;
Inert atmosphere;
DOI:10.1021/jacs.6b13389
- Guidance literature:
-
Multi-step reaction with 2 steps
1: toluene / 12 h / Reflux
2: dipotassium hydrogenphosphate; oxygen; tetrakis(acetonitrile)palladium bistriflate; N-((S)-2,2-dimethyl-1-((S)-4-(4-(trifluoromethyl)benzyl)-4,5-dihydrooxazol-2-yl)propyl)acetamide / acetonitrile; 1,2-dichloro-ethane; water / 15 h / 80 °C / Schlenk technique
With
dipotassium hydrogenphosphate; tetrakis(acetonitrile)palladium bistriflate; N-((S)-2,2-dimethyl-1-((S)-4-(4-(trifluoromethyl)benzyl)-4,5-dihydrooxazol-2-yl)propyl)acetamide; oxygen;
In
water; 1,2-dichloro-ethane; toluene; acetonitrile;
DOI:10.1021/jacs.6b13389
- Guidance literature:
-
Multi-step reaction with 3 steps
1: toluene / 12 h / Reflux
2: dipotassium hydrogenphosphate; oxygen; tetrakis(acetonitrile)palladium bistriflate; N-((S)-2,2-dimethyl-1-((S)-4-(4-(trifluoromethyl)benzyl)-4,5-dihydrooxazol-2-yl)propyl)acetamide / acetonitrile; 1,2-dichloro-ethane; water / 15 h / 80 °C / Schlenk technique
3: sodium dihydrogenphosphate; dihydrogen peroxide / water; tetrahydrofuran / 2 h / 0 - 20 °C
With
dipotassium hydrogenphosphate; sodium dihydrogenphosphate; tetrakis(acetonitrile)palladium bistriflate; N-((S)-2,2-dimethyl-1-((S)-4-(4-(trifluoromethyl)benzyl)-4,5-dihydrooxazol-2-yl)propyl)acetamide; dihydrogen peroxide; oxygen;
In
tetrahydrofuran; water; 1,2-dichloro-ethane; toluene; acetonitrile;
DOI:10.1021/jacs.6b13389
