4c-Methyl-cyclohexan-1r-carbonsaeure-chlorid

Base Information

• Chemical Name: 4c-Methyl-cyclohexan-1r-carbonsaeure-chlorid
• CAS No.: 55930-21-7
• Molecular Formula: C₈H₁₃ClO
• Molecular Weight: 160.644
• Mol file: 55930-21-7.mol

Synonyms:

Chemical Property of 4c-Methyl-cyclohexan-1r-carbonsaeure-chlorid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4c-Methyl-cyclohexan-1r-carbonsaeure-chlorid

There total 1 articles about 4c-Methyl-cyclohexan-1r-carbonsaeure-chlorid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(cis)-4-methylcyclohexanecarboxylic acid (934-67-8) → 4c-Methyl-cyclohexan-1r-carbonsaeure-chlorid (55930-21-7)

Guidance literature:

With oxalyl dichloride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jacs.6b13389

Reference yield:

4c-Methyl-cyclohexan-1r-carbonsaeure-chlorid (55930-21-7) → C21H25BF7NO3

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 12 h / Reflux

2: dipotassium hydrogenphosphate; oxygen; tetrakis(acetonitrile)palladium bistriflate; N-((S)-2,2-dimethyl-1-((S)-4-(4-(trifluoromethyl)benzyl)-4,5-dihydrooxazol-2-yl)propyl)acetamide / acetonitrile; 1,2-dichloro-ethane; water / 15 h / 80 °C / Schlenk technique

With dipotassium hydrogenphosphate; tetrakis(acetonitrile)palladium bistriflate; N-((S)-2,2-dimethyl-1-((S)-4-(4-(trifluoromethyl)benzyl)-4,5-dihydrooxazol-2-yl)propyl)acetamide; oxygen; In water; 1,2-dichloro-ethane; toluene; acetonitrile;

DOI:10.1021/jacs.6b13389

Reference yield:

4c-Methyl-cyclohexan-1r-carbonsaeure-chlorid (55930-21-7) → 2-hydroxy-4-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)cyclohexane-1-carboxamide

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / 12 h / Reflux

2: dipotassium hydrogenphosphate; oxygen; tetrakis(acetonitrile)palladium bistriflate; N-((S)-2,2-dimethyl-1-((S)-4-(4-(trifluoromethyl)benzyl)-4,5-dihydrooxazol-2-yl)propyl)acetamide / acetonitrile; 1,2-dichloro-ethane; water / 15 h / 80 °C / Schlenk technique

3: sodium dihydrogenphosphate; dihydrogen peroxide / water; tetrahydrofuran / 2 h / 0 - 20 °C

With dipotassium hydrogenphosphate; sodium dihydrogenphosphate; tetrakis(acetonitrile)palladium bistriflate; N-((S)-2,2-dimethyl-1-((S)-4-(4-(trifluoromethyl)benzyl)-4,5-dihydrooxazol-2-yl)propyl)acetamide; dihydrogen peroxide; oxygen; In tetrahydrofuran; water; 1,2-dichloro-ethane; toluene; acetonitrile;

DOI:10.1021/jacs.6b13389

upstream raw materials:

(cis)-4-methylcyclohexanecarboxylic acid