(2-{3-[3-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzylsulfanyl}-ethyl)-carbamic acid tert-butyl ester

Base Information

• Chemical Name: (2-{3-[3-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzylsulfanyl}-ethyl)-carbamic acid tert-butyl ester
• CAS No.: 1026544-27-3
• Molecular Formula: C₃₁H₃₅N₅O₄S
• Molecular Weight: 573.716
• Mol file: 1026544-27-3.mol

Synonyms:

Chemical Property of (2-{3-[3-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzylsulfanyl}-ethyl)-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-{3-[3-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzylsulfanyl}-ethyl)-carbamic acid tert-butyl ester

There total 3 articles about (2-{3-[3-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzylsulfanyl}-ethyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-acetoxymethylphenyl isocyanate → (2-{3-[3-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzylsulfanyl}-ethyl)-carbamic acid tert-butyl ester (1026544-27-3)

Guidance literature:

Multi-step reaction with 3 steps

2: aq. KOH / methanol

3: Ph₃P, DEAD / tetrahydrofuran / 1 h / Ambient temperature

With potassium hydroxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol;

DOI:10.1248/cpb.45.116

Reference yield:

Acetic acid 3-[3-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzyl ester (168017-83-2) → (2-{3-[3-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzylsulfanyl}-ethyl)-carbamic acid tert-butyl ester (1026544-27-3)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. KOH / methanol

2: Ph₃P, DEAD / tetrahydrofuran / 1 h / Ambient temperature

With potassium hydroxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol;

DOI:10.1248/cpb.45.116

Reference yield:

2-[(tert-butoxycarbonyl)amino]-1-ethanethiol (67385-09-5) + 1-(3-Hydroxymethyl-phenyl)-3-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-urea (153825-72-0) → (2-{3-[3-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzylsulfanyl}-ethyl)-carbamic acid tert-butyl ester (1026544-27-3)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 1h; Ambient temperature;

DOI:10.1248/cpb.45.116

upstream raw materials:

2-[(tert-butoxycarbonyl)amino]-1-ethanethiol

1-(3-Hydroxymethyl-phenyl)-3-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-urea

Acetic acid 3-[3-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzyl ester

Downstream raw materials:

(R)-1-[3-(2-aminoethylthiomethyl)phenyl]-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)urea