succinimidyl 5(S)-<ε-(butyloxycarbonyl)-N^α-(cyclobutylcarbonyl)-L-lysyl>amino>-4-oxo-6-phenylhexanoate

Base Information

• Chemical Name: succinimidyl 5(S)-<ε-(butyloxycarbonyl)-N^α-(cyclobutylcarbonyl)-L-lysyl>amino>-4-oxo-6-phenylhexanoate
• CAS No.: 96792-13-1
• Molecular Formula: C₃₂H₄₄N₄O₉
• Molecular Weight: 628.723

Synonyms:

Chemical Property of succinimidyl 5(S)-<ε-(butyloxycarbonyl)-N^α-(cyclobutylcarbonyl)-L-lysyl>amino>-4-oxo-6-phenylhexanoate

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of succinimidyl 5(S)-<ε-(butyloxycarbonyl)-N^α-(cyclobutylcarbonyl)-L-lysyl>amino>-4-oxo-6-phenylhexanoate

There total 3 articles about succinimidyl 5(S)-<ε-(butyloxycarbonyl)-N^α-(cyclobutylcarbonyl)-L-lysyl>amino>-4-oxo-6-phenylhexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → succinimidyl 5(S)-<ε-(butyloxycarbonyl)-Nα-(cyclobutylcarbonyl)-L-lysyl>amino>-4-oxo-6-phenylhexanoate (96792-13-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) CrO₃, H₂SO₄, 2.) 2N HCl, H₂, 3.) 90percent aq. CF₃COOH, 4.) Et₃N

2: dicyclohexylcarbodiimide / CH₂Cl₂; dimethylformamide / 20 h / Ambient temperature

With chromium(VI) oxide; hydrogenchloride; sulfuric acid; hydrogen; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00146a015

Reference yield:

2-<2-(1,3-dioxolan-2-yl)ethyl>-2-<1(S)-<ε-(benzyloxycarbonyl)-Nα-(cyclobutylcarbonyl)-L-lysyl>amino>-2-phenylethyl>-1,3-dioxolane (96792-08-4) → succinimidyl 5(S)-<ε-(butyloxycarbonyl)-Nα-(cyclobutylcarbonyl)-L-lysyl>amino>-4-oxo-6-phenylhexanoate (96792-13-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) CrO₃, H₂SO₄, 2.) 2N HCl, H₂, 3.) 90percent aq. CF₃COOH, 4.) Et₃N

2: dicyclohexylcarbodiimide / CH₂Cl₂; dimethylformamide / 20 h / Ambient temperature

With chromium(VI) oxide; hydrogenchloride; sulfuric acid; hydrogen; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00146a015

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 5(S)-<ε-(butyloxycarbonyl)-Nα-(cyclobutylcarbonyl)-L-lysyl>amino>-4-oxo-6-phenylhexanoic acid (96792-09-5) → succinimidyl 5(S)-<ε-(butyloxycarbonyl)-Nα-(cyclobutylcarbonyl)-L-lysyl>amino>-4-oxo-6-phenylhexanoate (96792-13-1)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; for 20h; Ambient temperature;

DOI:10.1021/jm00146a015

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

5(S)-<ε-(butyloxycarbonyl)-N^α-(cyclobutylcarbonyl)-L-lysyl>amino>-4-oxo-6-phenylhexanoic acid

di-tert-butyl dicarbonate

2-<2-(1,3-dioxolan-2-yl)ethyl>-2-<1(S)-<ε-(benzyloxycarbonyl)-N^α-(cyclobutylcarbonyl)-L-lysyl>amino>-2-phenylethyl>-1,3-dioxolane

Downstream raw materials:

5(S)-<ε-(butyloxycarbonyl)-N^α-(cyclobutylcarbonyl)-L-lysyl>amino>-4-oxo-6-phenylhexanoyl-L-proline hydroxylamide

5(S)-<α-(cyclobutylcarbonyl)-L-lysyl>amino>-4-oxo-6-phenylhexanoyl-L-proline hydroxylamide

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