2-((3-Methoxyphenyl)amino)-4-quinolinecarboxylic acid 2-(1-piperidinylacetyl)hydrazide

Base Information

Chemical Name:2-((3-Methoxyphenyl)amino)-4-quinolinecarboxylic acid 2-(1-piperidinylacetyl)hydrazide
CAS No.:134721-85-0
Molecular Formula:C₂₄H₂₇N₅O₃
Molecular Weight:433.51
Hs Code.:
DSSTox Substance ID:DTXSID80928733
Mol file:134721-85-0.mol

Synonyms:BRN 4829061;2-((3-Methoxyphenyl)amino)-4-quinolinecarboxylic acid 2-(1-piperidinylacetyl)hydrazide;4-Quinolinecarboxylic acid, 2-((3-methoxyphenyl)amino)-, 2-(1-piperidinylacetyl)hydrazide;134721-85-0;DTXSID80928733;LS-141662;N-[1-(3,4-Dihydropyridin-1(2H)-yl)-1-hydroxyethyl]-2-[(3-methoxyphenyl)imino]-1,2-dihydroquinoline-4-carbohydrazonic acid

Suppliers and Price of 2-((3-Methoxyphenyl)amino)-4-quinolinecarboxylic acid 2-(1-piperidinylacetyl)hydrazide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2-((3-Methoxyphenyl)amino)-4-quinolinecarboxylic acid 2-(1-piperidinylacetyl)hydrazide

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:7
Exact Mass:433.21138974
Heavy Atom Count:32
Complexity:662

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(NNC(=O)C1=CC(=NC2=CC=CC=C21)NC3=CC(=CC=C3)OC)(N4CCCC=C4)O

Technology Process of 2-((3-Methoxyphenyl)amino)-4-quinolinecarboxylic acid 2-(1-piperidinylacetyl)hydrazide

There total 3 articles about 2-((3-Methoxyphenyl)amino)-4-quinolinecarboxylic acid 2-(1-piperidinylacetyl)hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 110-89-4
piperidine

: 134721-77-0
2-(3-Methoxy-phenylamino)-quinoline-4-carboxylic acid N'-(2-chloro-acetyl)-hydrazide

: 134721-85-0
2-(3-Methoxy-phenylamino)-quinoline-4-carboxylic acid N'-(2-piperidin-1-yl-acetyl)-hydrazide

Guidance literature:: In 1,4-dioxane; for 1h; Heating;
DOI:10.1007/BF00772014

Reference yield:

: 134721-71-4
2-(3-Methoxy-phenylamino)-quinoline-4-carboxylic acid hydrazide

: 134721-85-0
2-(3-Methoxy-phenylamino)-quinoline-4-carboxylic acid N'-(2-piperidin-1-yl-acetyl)-hydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / NaOAc, acetic acid / 24 h / Ambient temperature

2: 66 percent / dioxane / 1 h / Heating

With sodium acetate; acetic acid; In 1,4-dioxane;
DOI:10.1007/BF00772014

Reference yield:

: 134721-65-6
2-(3-Methoxy-phenylamino)-quinoline-4-carboxylic acid ethyl ester

: 134721-85-0
2-(3-Methoxy-phenylamino)-quinoline-4-carboxylic acid N'-(2-piperidin-1-yl-acetyl)-hydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / hydrazine hydrate / ethanol / 2 h / Heating

2: 88 percent / NaOAc, acetic acid / 24 h / Ambient temperature

3: 66 percent / dioxane / 1 h / Heating

With sodium acetate; hydrazine hydrate; acetic acid; In 1,4-dioxane; ethanol;
DOI:10.1007/BF00772014