(3-{(1R,2S,3R)-2-[(E)-(S)-4-(4-Chloro-phenyl)-3-hydroxy-but-1-enyl]-3-hydroxy-5-oxo-cyclopentylsulfanyl}-propylsulfanyl)-acetic acid methyl ester

Base Information

Chemical Name:(3-{(1R,2S,3R)-2-[(E)-(S)-4-(4-Chloro-phenyl)-3-hydroxy-but-1-enyl]-3-hydroxy-5-oxo-cyclopentylsulfanyl}-propylsulfanyl)-acetic acid methyl ester
CAS No.:540731-37-1
Molecular Formula:C₂₁H₂₇ClO₅S₂
Molecular Weight:459.027
Hs Code.:

(3-{(1R,2S,3R)-2-[(E)-(S)-4-(4-Chloro-phenyl)-3-hydroxy-but-1-enyl]-3-hydroxy-5-oxo-cyclopentylsulfanyl}-propylsulfanyl)-acetic acid methyl ester

Synonyms:

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Chemical Property of (3-{(1R,2S,3R)-2-[(E)-(S)-4-(4-Chloro-phenyl)-3-hydroxy-but-1-enyl]-3-hydroxy-5-oxo-cyclopentylsulfanyl}-propylsulfanyl)-acetic acid methyl ester

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Technology Process of (3-{(1R,2S,3R)-2-[(E)-(S)-4-(4-Chloro-phenyl)-3-hydroxy-but-1-enyl]-3-hydroxy-5-oxo-cyclopentylsulfanyl}-propylsulfanyl)-acetic acid methyl ester

There total 5 articles about (3-{(1R,2S,3R)-2-[(E)-(S)-4-(4-Chloro-phenyl)-3-hydroxy-but-1-enyl]-3-hydroxy-5-oxo-cyclopentylsulfanyl}-propylsulfanyl)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 433230-16-1
(3-{(4R,5S)-2-Acetoxy-5-[(E)-(S)-4-(4-chloro-phenyl)-3-hydroxy-but-1-enyl]-4-hydroxy-cyclopent-1-enylsulfanyl}-propylsulfanyl)-acetic acid methyl ester

: 540731-37-1
(3-{(1R,2S,3R)-2-[(E)-(S)-4-(4-Chloro-phenyl)-3-hydroxy-but-1-enyl]-3-hydroxy-5-oxo-cyclopentylsulfanyl}-propylsulfanyl)-acetic acid methyl ester

Guidance literature:: With Amano PS; In phosphate buffer; dimethyl sulfoxide; at 20 ℃; for 3h; pH=7.4;
DOI:10.1016/S0968-0896(01)00352-2

Reference yield:

: 4251-65-4
(4-chlorophenyl)acetaldehyde

: 540731-37-1
(3-{(1R,2S,3R)-2-[(E)-(S)-4-(4-Chloro-phenyl)-3-hydroxy-but-1-enyl]-3-hydroxy-5-oxo-cyclopentylsulfanyl}-propylsulfanyl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / CrCl₂; NiCl₂ / dimethylformamide / 1 h / 20 °C

2: 47 percent / pyridinium poly(hydrogen fluoride) / acetonitrile; pyridine / 0.5 h

3: Amano PS / dimethylsulfoxide; aq. phosphate buffer / 3 h / 20 °C / pH 7.4

With chromium dichloride; Amano PS; pyridine hydrogenfluoride; nickel dichloride; In pyridine; phosphate buffer; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; 1: Hiyama coupling;
DOI:10.1016/S0968-0896(01)00352-2

Reference yield:

: 433228-93-4
(3S,4R)-1-acetoxy-4-(tert-butyldimethylsiloxy)-3-(trans-2-iodovinyl)-2-(6-methoxycarbonyl-1,5-dithiahexyl)-1-cyclopentene

: 540731-37-1
(3-{(1R,2S,3R)-2-[(E)-(S)-4-(4-Chloro-phenyl)-3-hydroxy-but-1-enyl]-3-hydroxy-5-oxo-cyclopentylsulfanyl}-propylsulfanyl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / CrCl₂; NiCl₂ / dimethylformamide / 1 h / 20 °C

2: 47 percent / pyridinium poly(hydrogen fluoride) / acetonitrile; pyridine / 0.5 h

3: Amano PS / dimethylsulfoxide; aq. phosphate buffer / 3 h / 20 °C / pH 7.4

With chromium dichloride; Amano PS; pyridine hydrogenfluoride; nickel dichloride; In pyridine; phosphate buffer; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; 1: Hiyama coupling;
DOI:10.1016/S0968-0896(01)00352-2