4251-65-4

Basic information

• Product Name: (4-CHLORO-PHENYL)-ACETALDEHYDE
• Synonyms: 2-(4-CHLOROPHENYL)ACETALDEHYDE;(4-CHLORO-PHENYL)-ACETALDEHYDE;(4-Chloro-phenyl)-etaldehyde;(4-chloro-phenyl0_acetaldehyde;2-(4-Chlorophenyl)ethanal;4-Chlorobenzeneacetaldehyde
• CAS NO: 4251-65-4
• Molecular Formula: C₈H₇ClO
• Molecular Weight: 154.59
• Product Categories: Aromatic Aldehydes & Derivatives (substituted);Aldehydes;Phenyls & Phenyl-Het
• Mol File: 4251-65-4.mol
• Article Data: 89

Chemical Properties

• Melting Point: 87-88 °C(Solv: benzene (71-43-2))
• Boiling Point: 235.8 °C at 760 mmHg
• Flash Point: 106.3 °C
• Appearance: /
• Density: 1.175 g/cm³
• Vapor Pressure: 0.049mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: (4-CHLORO-PHENYL)-ACETALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-CHLORO-PHENYL)-ACETALDEHYDE(4251-65-4)
• EPA Substance Registry System: (4-CHLORO-PHENYL)-ACETALDEHYDE(4251-65-4)

Safety Data

• Hazardous Substances Data: 4251-65-4(Hazardous Substances Data)

Usage

General Description

(4-Chloro-phenyl)-acetaldehyde is a chemical compound that belongs to the class of organic compounds known as phenylacetaldehydes. Its IUPAC name is 1-(4-Chlorophenyl)ethanal. The chemical formula for the compound is C8H7ClO and its molecular weight is 154.59 g/mol. It contains a phenyl group (a ring of six carbon atoms) substituted with a chlorine atom and attached to an acetaldehyde group. (4-CHLORO-PHENYL)-ACETALDEHYDE is used in the synthesis of other chemicals and is typically handled with care due to its potentially harmful nature. A precise safety assessment should be considered by professionals in chemistry before its usage.

InChI:InChI=1/C8H7ClO/c9-8-3-1-7(2-4-8)5-6-10/h1-4,6H,5H2

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 105-39-5 chloroacetic acid ethyl ester 
• 140-53-4 p-chlorobenzyl cyanide 
• 81321-33-7 (E)-N-[2-(4-Chlorophenyl)ethenyl]morpholine 
• 956-04-7 3-(4-chlorophenyl)-1-phenylprop-2-en-1-one 
• 62879-80-5 (E)-1-(4-chlorostyryl)piperidine 
• 19493-09-5 Methylenetriphenylphosphorane 
• 1005-62-5 4-tolyl vinyl ether 
• 106-47-8 4-chloro-aniline 
• 766-94-9 vinyl phenyl ether 
• 2028-74-2 p-chlorobenzenediazonium chloride 
• 1073-67-2 4-vinylbenzyl chloride 
• 64-18-6 formic acid 
• 873-76-7 para-Chlorobenzyl alcohol 

Downstream Products

• 1550-92-1 3-(4-chloro-benzyl)-1,1-dioxo-6-trifluoromethyl-1,2,3,4-tetrahydro-1λ⁶-benzo[1,2,4]thiadiazine-7-sulfonic acid amide 
• 157457-71-1 (2S,3R)-2-Amino-3-hydroxy-4-(4-chlorophenyl)butanoic acid 
• 14091-10-2 (S)-2-acetamido-3-(4-chlorophenyl)propanoic acid 
• 14091-10-2 N-acetyl-4-chlorophenylalanine 
• 1878-66-6 4-chlorophenylacetic Acid 
• 528578-00-9 C₂₁H₂₂ClNO₄ 
• 1287736-95-1 3,5-bis(4-chlorophenyl)-2-phenylpyridine 
• 1345988-92-2 C₁₄H₁₅ClO₂ 
• 1131282-63-7 C₁₄H₁₅ClO₂ 

Relevant articles and documents

Oxidation of certain 4-substituted phenethyl alcohols with Collins reagent: On the mechanism of a carbon-carbon bond cleavage

A mechanism is proposed for a carbon-carbon bond cleavage observed in the oxidation of certain 4-substituted phenethyl alcohols with Collins reagent.

High-Level Production of Phenylacetaldehyde using Fusion-Tagged Styrene Oxide Isomerase

An order-of-magnitude improvement in the production of phenylacetaldehyde to 3.37 M (405 g L?1) from the enzymatic isomerisation of styrene oxide was achieved. A small ubiquitin-related modifier (SUMO) tag increases the productivity of the whole-cell biocatalytic system by enhancing the expression of active membrane-bound styrene oxide isomerase (SOI) while retaining enzyme catalytic efficiency and broad natural substrate scope. The isomerisation was performed by using Escherichia coli expressing SUMO-tagged SOI in an organic-aqueous biphasic system to yield 96% of phenylacetaldehyde. (Figure presented.).

Regioselective, Diastereoselective, and Enantioselective One-Pot Tandem Reaction Based on an in Situ Formed Reductant: Preparation of 2,3-Disubstituted 1,5-Benzodiazepine

The 1,5-benzodiazepines are important skeletons frequently contained in medicinal chemistry. Herein, we described an unexpected tandem cyclization/transfer hydrogenation reaction for obtaining chiral 2,3-disubstituted 1,5-benzodiazepines. The enolizable aryl aldehydes were chosen as substrates to react with symmetric and unsymmetric o-phenylenediamines. The unforeseen tandem reaction occurred among many possible latent side reactions under chiral phosphoric acid catalysis and affords the corresponding products in moderate yields and regioselectivities, good diastereoselectivities, and enantiomeric ratio (up to 99:1).