1-(2-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-<2-(4-nitrophenyl)ethyl>>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole

Base Information

• Chemical Name: 1-(2-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-<2-(4-nitrophenyl)ethyl>>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole
• CAS No.: 137016-82-1
• Molecular Formula: C₅₀H₇₂Cl₄N₅O₁₂PSi₃
• Molecular Weight: 1192.19
• Mol file: 137016-82-1.mol

Synonyms:

Chemical Property of 1-(2-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-<2-(4-nitrophenyl)ethyl>>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-<2-(4-nitrophenyl)ethyl>>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole

There total 13 articles about 1-(2-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-<2-(4-nitrophenyl)ethyl>>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-(2-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-2-(4-nitrophenyl)ethyl>->5'>-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole (137016-80-9,137119-97-2) → 1-(2-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-<2-(4-nitrophenyl)ethyl>>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole (137016-82-1,137119-99-4)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; dichloromethane; for 6h; Ambient temperature;

DOI:10.1016/0008-6215(92)84178-U

Reference yield:

5,6-dichlorobenzimidazole (6478-73-5) → 1-(2-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-<2-(4-nitrophenyl)ethyl>>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole (137016-82-1,137119-99-4)

Guidance literature:

Multi-step reaction with 8 steps

1: 51 percent / p-TsOH / 1 h / 170 - 180 °C / 20 Torr

2: NaOMe / methanol

3: 87 percent / pyridine / Ambient temperature

4: 20 percent / pyridine / 18 h / Ambient temperature

6: 1) 4-nitrobenzaldoxime, H₂O / 1) dioxane, r.t., 20 min, 2) 6 h

7: 50 percent / N-methylimidazole, 2,4,6-tri-isopropylbenzenesulfonyl chloride / pyridine / 66 h / Ambient temperature

8: 85 percent / p-TsOH / CH₂Cl₂; methanol / 6 h / Ambient temperature

With pyridine; 1-methyl-1H-imidazole; 2,4,6-triisopropylphenylsulfonyl chloride; water; sodium methylate; toluene-4-sulfonic acid; 4-nitrobenzaldehyde oxime; In pyridine; methanol; dichloromethane;

DOI:10.1016/0008-6215(92)84178-U

Reference yield:

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (6974-32-9) → 1-(2-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-<2-(4-nitrophenyl)ethyl>>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole (137016-82-1,137119-99-4)

Guidance literature:

Multi-step reaction with 8 steps

1: 51 percent / p-TsOH / 1 h / 170 - 180 °C / 20 Torr

2: NaOMe / methanol

3: 87 percent / pyridine / Ambient temperature

4: 20 percent / pyridine / 18 h / Ambient temperature

6: 1) 4-nitrobenzaldoxime, H₂O / 1) dioxane, r.t., 20 min, 2) 6 h

7: 50 percent / N-methylimidazole, 2,4,6-tri-isopropylbenzenesulfonyl chloride / pyridine / 66 h / Ambient temperature

8: 85 percent / p-TsOH / CH₂Cl₂; methanol / 6 h / Ambient temperature

With pyridine; 1-methyl-1H-imidazole; 2,4,6-triisopropylphenylsulfonyl chloride; water; sodium methylate; toluene-4-sulfonic acid; 4-nitrobenzaldehyde oxime; In pyridine; methanol; dichloromethane;

DOI:10.1016/0008-6215(92)84178-U

upstream raw materials:

1-(2-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-2-(4-nitrophenyl)ethyl>->5'>-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

5,6-dichlorobenzimidazole

5,6-dichloro-1-β-D-ribobenzimidazole

Downstream raw materials:

C₉₆H₁₂₀Cl₆N₈O₂₁P₂Si₄