(S)-1-[2-[[Hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxopropyl]-L-proline, dilithium salt

Base Information

Chemical Name:(S)-1-[2-[[Hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxopropyl]-L-proline, dilithium salt
CAS No.:89537-15-5
Molecular Formula:C₁₈H₂₄NO₆P*2Li
Molecular Weight:395.247
Hs Code.:

Synonyms:

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Chemical Property of (S)-1-[2-[[Hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxopropyl]-L-proline, dilithium salt

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Technology Process of (S)-1-[2-[[Hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxopropyl]-L-proline, dilithium salt

There total 8 articles about (S)-1-[2-[[Hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxopropyl]-L-proline, dilithium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16652-71-4
benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride

: 89537-15-5,106061-77-2
(S)-1-[2-[[Hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxopropyl]-L-proline, dilithium salt

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / diphenylphosphoryl azide, triethylamine / dimethylformamide / 24 h / Ambient temperature

2: dicyclohexylcarbodiimide / pyridine / 1.5 h / 80 °C

3: 1.) H₂, 2.) AG₅₀W-X₈(Li+) / 1.) Pd(OH)2-C / other cond.: 1.) methanol

With AG₅₀W-X₈(Li+); diphenylphosphoranyl azide; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium hydroxide - carbon; In pyridine; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)84364-6

Reference yield:

: 89537-18-8
1-<(S)-2-hydroxy-1-oxopropyl>-L-proline phenylmethyl ester

: 89537-15-5,106061-77-2
(S)-1-[2-[[Hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxopropyl]-L-proline, dilithium salt

Guidance literature:: Multi-step reaction with 2 steps

1: dicyclohexylcarbodiimide / pyridine / 1.5 h / 80 °C

2: 1.) H₂, 2.) AG₅₀W-X₈(Li+) / 1.) Pd(OH)2-C / other cond.: 1.) methanol

With AG₅₀W-X₈(Li+); hydrogen; dicyclohexyl-carbodiimide; palladium hydroxide - carbon; In pyridine;
DOI:10.1016/S0040-4039(00)84364-6

Reference yield:

: 768-56-9
4-Phenylbut-1-ene

: 89537-15-5,106061-77-2
(S)-1-[2-[[Hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxopropyl]-L-proline, dilithium salt

Guidance literature:: Multi-step reaction with 4 steps

1: NaH₂PO₂*H₂O, H₂SO₄, AIBN / ethanol / 16 h / Heating

2: dicyclohexylcarbodiimide, N,N-dimethylaminopyridine / tetrahydrofuran / 2 h / Ambient temperature

3: sodium metaperiodate / dioxane; H₂O / 16 h / Ambient temperature

4: 1.) H₂, 2.) AG₅₀W-X₈(Li+) / 1.) Pd(OH)2-C / other cond.: 1.) methanol

With dmap; sodium periodate; sodium hypophosphite; 2,2'-azobis(isobutyronitrile); AG₅₀W-X₈(Li+); sulfuric acid; hydrogen; dicyclohexyl-carbodiimide; isobutyric Acid; palladium hydroxide - carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; water;
DOI:10.1016/S0040-4039(00)84364-6