Technology Process of 2-[2-(2-fluorobenzoylamino)-benzoylamino]-4,5-difluorobenzoic acid
There total 9 articles about 2-[2-(2-fluorobenzoylamino)-benzoylamino]-4,5-difluorobenzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C22H15F3N2O4;
With
pyridine; sodium hydroxide;
In
water;
at 20 ℃;
for 2h;
With
hydrogenchloride;
In
water; ethyl acetate;
DOI:10.1021/jm201636v
- Guidance literature:
-
Multi-step reaction with 5 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / 1,2-dichloro-ethane / 0.67 h / 20 °C / Inert atmosphere
2: pyridine / 1,2-dichloro-ethane / 20 °C / Inert atmosphere
3: palladium on activated charcoal; hydrogen / methanol; ethyl acetate / 5 h / 760.05 Torr
4: pyridine / 1,2-dichloro-ethane / 20 °C / Inert atmosphere
5: pyridine; sodium hydroxide / water / 2 h / 20 °C
With
pyridine; oxalyl dichloride; palladium on activated charcoal; hydrogen; N,N-dimethyl-formamide; sodium hydroxide;
In
methanol; water; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1021/jm201636v
- Guidance literature:
-
Multi-step reaction with 4 steps
1: pyridine / 1,2-dichloro-ethane / 20 °C / Inert atmosphere
2: palladium on activated charcoal; hydrogen / methanol; ethyl acetate / 5 h / 760.05 Torr
3: pyridine / 1,2-dichloro-ethane / 20 °C / Inert atmosphere
4: pyridine; sodium hydroxide / water / 2 h / 20 °C
With
pyridine; palladium on activated charcoal; hydrogen; sodium hydroxide;
In
methanol; water; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1021/jm201636v
